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    Lamc2 laminin, gamma 2 [ Mus musculus (house mouse) ]

    Gene ID: 16782, updated on 3-Oct-2018

    Summary

    Official Symbol
    Lamc2provided by MGI
    Official Full Name
    laminin, gamma 2provided by MGI
    Primary source
    MGI:MGI:99913
    See related
    Ensembl:ENSMUSG00000026479 Vega:OTTMUSG00000049711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA589349
    Expression
    Broad expression in lung adult (RPKM 15.7), colon adult (RPKM 6.6) and 16 other tissues See more
    Orthologs

    Genomic context

    See Lamc2 in Genome Data Viewer
    Location:
    1 G3; 1 65.26 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (153122756..153186447, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (154969886..155033577, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene nicotinamide nucleotide adenylyltransferase 2 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene laminin, gamma 1 Neighboring gene predicted pseudogene 8818 Neighboring gene predicted gene, 46246

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    extracellular matrix structural constituent HDA PubMed 
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    basement membrane assembly IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    collagen-containing extracellular matrix HDA PubMed 
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    laminin-2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    laminin-5 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    laminin subunit gamma-2
    Names
    epiligrin subunit gamma
    kalinin subunit gamma
    kalinin/nicein/epiligrin 100 kDa subunit
    laminin B2t chain
    laminin gamma2 chain
    laminin-5 subunit gamma
    nicein subunit gamma
    nicein, 100kD
    nicein, 100kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008485.3NP_032511.3  laminin subunit gamma-2 precursor

      See identical proteins and their annotated locations for NP_032511.3

      Status: VALIDATED

      Source sequence(s)
      AC099735, BB617855, BU758039, CF733033, CJ094114, DV654715, DV658346
      Consensus CDS
      CCDS15369.1
      UniProtKB/TrEMBL
      G5E874
      Related
      ENSMUSP00000027753.6, ENSMUST00000027753.12
      Conserved Domains (6) summary
      cd00055
      Location:83127
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00185
      Location:445481
      TNFRSF; CRD2 [structural motif]
      pfam00052
      Location:250370
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:139184
      Laminin_EGF; Laminin EGF domain
      cl22855
      Location:437501
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
      cl23750
      Location:9481065
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      153122756..153186447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247927.1XP_011246229.1  laminin subunit gamma-2 isoform X2

      Conserved Domains (7) summary
      smart00180
      Location:2765
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:509541
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00185
      Location:382418
      TNFRSF; CRD2 [structural motif]
      pfam00052
      Location:187307
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:76121
      Laminin_EGF; Laminin EGF domain
      cl22855
      Location:374438
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
      cl23750
      Location:8851002
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    2. XM_011247926.2XP_011246228.1  laminin subunit gamma-2 isoform X1

      See identical proteins and their annotated locations for XP_011246228.1

      UniProtKB/TrEMBL
      G5E874
      Related
      ENSMUSP00000140514.1, OTTMUSP00000068446, ENSMUST00000185356.6, OTTMUST00000126618
      Conserved Domains (6) summary
      cd00055
      Location:83127
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00185
      Location:445481
      TNFRSF; CRD2 [structural motif]
      pfam00052
      Location:250370
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:139184
      Laminin_EGF; Laminin EGF domain
      cl22855
      Location:437501
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
      cl23750
      Location:9481065
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
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