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    AP2B1 adaptor related protein complex 2 subunit beta 1 [ Homo sapiens (human) ]

    Gene ID: 163, updated on 7-Apr-2024

    Summary

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    Official Symbol
    AP2B1provided by HGNC
    Official Full Name
    adaptor related protein complex 2 subunit beta 1provided by HGNC
    Primary source
    HGNC:HGNC:563
    See related
    Ensembl:ENSG00000006125 MIM:601025; AllianceGenome:HGNC:563
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADTB2; AP105B; CLAPB1; AP2-BETA
    Summary
    The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 64.4), testis (RPKM 50.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    17q12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35587322..35726413)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36535193..36674326)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33914341..34053432)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:33904854-33905669 Neighboring gene small nucleolar RNA host gene 30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12077 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:33914287-33915486 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene transmembrane protein 160 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:33957282-33958481 Neighboring gene MPRA-validated peak2820 silencer Neighboring gene Sharpr-MPRA regulatory region 1039 Neighboring gene ribosomal protein L17 pseudogene 42 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34059551-34060074 Neighboring gene RAS like family 10 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12079 Neighboring gene growth arrest specific 2 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Paing MM, et al. Mol Cell Biol, 2006 Apr. PMID 16581796, Free PMC Article
    2. Expression of a novel beta adaptin subunit mRNA splice variant in human testes. Zhang XD, et al. Asian J Androl, 2005 Jun. PMID 15897975
    3. The structure and function of the beta 2-adaptin appendage domain. Owen DJ, et al. EMBO J, 2000 Aug 15. PMID 10944104, Free PMC Article
    4. Prevalence of Polymorphism and Post-Training Expression of ACTN3 (R/X) and ACE (I/D) Genes in CrossFit Athletes. Peña-Vázquez O, et al. Int J Environ Res Public Health, 2023 Mar 1. PMID 36901413, Free PMC Article
    5. AP-2β inhibits hepatocellular carcinoma invasion and metastasis through Slug and Snail to suppress epithelial-mesenchymal transition. Yang L, et al. Theranostics, 2018. PMID 30026878, Free PMC Article

    See all (216) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Principal components analysis to evaluate complex association of polymorphisms in ACE and ACTN3 genes and the extent of cardiovascular adaptive changes in elite athletes.
      Title: Principal components analysis to evaluate complex association of polymorphisms in ACE and ACTN3 genes and the extent of cardiovascular adaptive changes in elite athletes.
    2. Polymorphisms of ACE and thrombophilic genes: risk for recurrent pregnancy loss.
      Title: Polymorphisms of ACE and thrombophilic genes: risk for recurrent pregnancy loss.
    3. Prevalence of Polymorphism and Post-Training Expression of ACTN3 (R/X) and ACE (I/D) Genes in CrossFit Athletes.
      Title: Prevalence of Polymorphism and Post-Training Expression of ACTN3 (R/X) and ACE (I/D) Genes in CrossFit Athletes.
    4. Reduced expression of AP-2beta was significantly associated with more advanced hepatocellular carcinoma stages and larger tumor sizes. The overexpression of AP-2beta reduced HCC proliferation, migration, invasion, tumor formation and metastasis in vitro and in vivo. Moreover, AP-2beta modulates the levels of epithelial-mesenchymal transition markers through Slug and Snail in hepatocellular carcinoma cell lines and tiss...
      Title: AP-2β inhibits hepatocellular carcinoma invasion and metastasis through Slug and Snail to suppress epithelial-mesenchymal transition.
    5. AP2B1 might be associated with the development of nonsyndromic cleft lip with or without cleft palate.
      Title: Associations of genetic variants in endocytic trafficking of epidermal growth factor receptor super pathway with risk of nonsyndromic cleft lip with or without cleft palate.
    6. this study determined a structure of AP2 that includes the clathrin-binding beta2 hinge.
      Title: Clathrin adaptors. AP2 controls clathrin polymerization with a membrane-activated switch.
    7. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    8. Results suggest that autosomal recessive hypercholesterolemia (ARH) and beta-arrestin depend on a privileged AP2beta2 appendage site for proper cargo recruitment to clathrin bud sites.
      Title: The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis.
    9. multiple interactions between PIPKI gamma-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin-mediated synaptic vesicle endocytosis
      Title: Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
    10. EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics.
      Title: Immunohistochemical detection of EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    New gene functions in megakaryopoiesis and platelet formation.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 Env gp41 requires the conserved membrane-proximal AP2B1 binding site in the gp41 cytoplasmic tail to evade antibody-dependent cell-mediated cytotoxicity (ADCC) via membrane-proximal endocytosis PubMed
    env Two independent motifs, a membrane proximal conserved GYxxO motif (residues 711-715) and a C-terminal dileucine motif (residues 855-856), of the HIV-1 gp41 protein mediate endocytosis through interaction with the clathrin adaptor AP-2 PubMed
    env The cytoplasmic domain (residues 707-856) of HIV-1 gp41 interacts with whole clathrin-associated AP-1 and AP-2 adaptor complexes PubMed
    Nef nef Clathrin and the clathrin-associated, plasma membrane-localized AP2 complexes are required for the HIV-1 Nef-mediated downregulation of CD4 PubMed
    nef A dileucine-motif-containing segment of Nef binds directly to the beta subunit of the clathrin adaptor complexes AP-2, which are responsible for recruiting sorted proteins into clathrin coated pits PubMed
    nef HIV-1 Nef co-localizes with the beta subunit of the adaptor protein complexes (AP-2) in human T cells; Nef residues 174-179 are required for the co-localization of Nef with the beta subunit PubMed
    nef In cells expressing an HIV-1 Nef-green fluorescent protein (GFP) fusion, CD28 co-localizes with the AP-2 clathrin adaptor and Nef-GFP PubMed
    Pr55(Gag) gag HIV-1 Gag binds to AP-2, and this binding is dependent on tyrosine residue 132 and valine residue 135 at the matrix-capsid junction in the Gag polyprotein PubMed
    Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of adaptor-related protein complex 2, beta 1 subunit (AP2B1) in U-937 macrophages PubMed
    tat HIV-1 Tat enters T cells by using clathrin/AP2-mediated endocytosis followed by low-pH-induced and Hsp90-assisted endosomal translocation, which leads to cell responses that are induced from the cytosol PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp781K0743

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to clathrin adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables clathrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables clathrin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signal sequence binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aorta development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clathrin-dependent endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in clathrin-dependent endocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in clathrin-dependent endocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in coronary vasculature development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postsynaptic neurotransmitter receptor internalization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventricular septum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of AP-2 adaptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of AP-2 adaptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of AP-2 adaptor complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of clathrin adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated endocytic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cytoplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in endolysosome membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP-2 complex subunit beta
    Names
    adapter-related protein complex 2 beta subunit
    adapter-related protein complex 2 subunit beta
    adaptin, beta 2 (beta)
    adaptor protein complex AP-2 subunit beta
    adaptor related protein complex 2 beta 1 subunit
    adaptor-related protein complex 2 subunit beta
    beta-2-adaptin
    beta-adaptin
    beta2-adaptin
    clathrin assembly protein complex 2 beta large chain
    clathrin-associated/assembly/adaptor protein, large, beta 1
    plasma membrane adaptor HA2/AP2 adaptin beta subunit
    testicular tissue protein Li 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030006.2 → NP_001025177.1  AP-2 complex subunit beta isoform a

      See identical proteins and their annotated locations for NP_001025177.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AI691147, BC006201, BC012150, BQ421703, BX643620, M34175
      Consensus CDS
      CCDS32621.1
      UniProtKB/TrEMBL
      A0A140VJE8, A8K0G3
      Related
      ENSP00000483185.1, ENST00000610402.5
      Conserved Domains (4) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    2. NM_001282.3 → NP_001273.1  AP-2 complex subunit beta isoform b

      See identical proteins and their annotated locations for NP_001273.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AI691147, BQ421703, BX643620, M34175
      Consensus CDS
      CCDS32622.1
      UniProtKB/Swiss-Prot
      A6NJP3, P21851, P63010, Q7Z451, Q96J19
      UniProtKB/TrEMBL
      A8K0G3
      Related
      ENSP00000482315.1, ENST00000621914.4
      Conserved Domains (4) summary
      smart00809
      Location:717 → 817
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:826 → 936
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      35587322..35726413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524450.3 → XP_011522752.1  AP-2 complex subunit beta isoform X1

      See identical proteins and their annotated locations for XP_011522752.1

      UniProtKB/TrEMBL
      A8K0G3
      Conserved Domains (4) summary
      smart00809
      Location:731 → 825
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:872 → 982
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    2. XM_005257938.4 → XP_005257995.1  AP-2 complex subunit beta isoform X3

      See identical proteins and their annotated locations for XP_005257995.1

      UniProtKB/TrEMBL
      A0A140VJE8, A8K0G3
      Related
      ENSP00000482835.1, ENST00000618940.4
      Conserved Domains (4) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    3. XM_047435509.1 → XP_047291465.1  AP-2 complex subunit beta isoform X2

    4. XM_047435510.1 → XP_047291466.1  AP-2 complex subunit beta isoform X4

      UniProtKB/Swiss-Prot
      A6NJP3, P21851, P63010, Q7Z451, Q96J19

    5. XM_011524449.4 → XP_011522751.1  AP-2 complex subunit beta isoform X1

      See identical proteins and their annotated locations for XP_011522751.1

      UniProtKB/TrEMBL
      A8K0G3
      Conserved Domains (4) summary
      smart00809
      Location:731 → 825
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:872 → 982
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    6. XM_005257937.5 → XP_005257994.1  AP-2 complex subunit beta isoform X3

      See identical proteins and their annotated locations for XP_005257994.1

      UniProtKB/TrEMBL
      A0A140VJE8, A8K0G3
      Conserved Domains (4) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    7. XM_047435508.1 → XP_047291464.1  AP-2 complex subunit beta isoform X2

    8. XM_017024284.3 → XP_016879773.1  AP-2 complex subunit beta isoform X4

      UniProtKB/Swiss-Prot
      A6NJP3, P21851, P63010, Q7Z451, Q96J19
      UniProtKB/TrEMBL
      A8K0G3
      Conserved Domains (4) summary
      smart00809
      Location:717 → 817
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:826 → 936
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    9. XM_011524448.3 → XP_011522750.1  AP-2 complex subunit beta isoform X1

      See identical proteins and their annotated locations for XP_011522750.1

      UniProtKB/TrEMBL
      A8K0G3
      Conserved Domains (4) summary
      smart00809
      Location:731 → 825
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:872 → 982
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    10. XM_011524451.3 → XP_011522753.1  AP-2 complex subunit beta isoform X2

      UniProtKB/TrEMBL
      A8K0G3
      Conserved Domains (4) summary
      smart00809
      Location:717 → 811
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:858 → 968
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    11. XM_047435512.1 → XP_047291468.1  AP-2 complex subunit beta isoform X6

      Related
      ENSP00000478115.1, ENST00000612116.5

    12. XM_017024287.3 → XP_016879776.1  AP-2 complex subunit beta isoform X6

      UniProtKB/TrEMBL
      A0A087WU93
      Related
      ENSP00000479691.1, ENST00000614600.4
      Conserved Domains (3) summary
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:99 → 268
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]

    13. XM_005257941.4 → XP_005257998.1  AP-2 complex subunit beta isoform X6

      UniProtKB/TrEMBL
      A0A087WU93
      Related
      ENSP00000478471.1, ENST00000616784.4
      Conserved Domains (3) summary
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:99 → 268
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]

    14. XM_047435511.1 → XP_047291467.1  AP-2 complex subunit beta isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      36535193..36674326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315296.1 → XP_054171271.1  AP-2 complex subunit beta isoform X6

    2. XM_054315295.1 → XP_054171270.1  AP-2 complex subunit beta isoform X6

    3. XM_054315284.1 → XP_054171259.1  AP-2 complex subunit beta isoform X1

    4. XM_054315287.1 → XP_054171262.1  AP-2 complex subunit beta isoform X2

    5. XM_054315290.1 → XP_054171265.1  AP-2 complex subunit beta isoform X3

      UniProtKB/TrEMBL
      A0A140VJE8

    6. XM_054315292.1 → XP_054171267.1  AP-2 complex subunit beta isoform X4

      UniProtKB/Swiss-Prot
      A6NJP3, P21851, P63010, Q7Z451, Q96J19

    7. XM_054315289.1 → XP_054171264.1  AP-2 complex subunit beta isoform X3

      UniProtKB/TrEMBL
      A0A140VJE8

    8. XM_054315291.1 → XP_054171266.1  AP-2 complex subunit beta isoform X4

      UniProtKB/Swiss-Prot
      A6NJP3, P21851, P63010, Q7Z451, Q96J19

    9. XM_054315283.1 → XP_054171258.1  AP-2 complex subunit beta isoform X1

    10. XM_054315286.1 → XP_054171261.1  AP-2 complex subunit beta isoform X2

    11. XM_054315294.1 → XP_054171269.1  AP-2 complex subunit beta isoform X6

    12. XM_054315285.1 → XP_054171260.1  AP-2 complex subunit beta isoform X1

    13. XM_054315288.1 → XP_054171263.1  AP-2 complex subunit beta isoform X2

    14. XM_054315293.1 → XP_054171268.1  AP-2 complex subunit beta isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63010.1 GenPept UniProtKB/Swiss-Prot:P63010

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