Format

Send to:

Choose Destination
    • Showing Current items.

    CLEC14A C-type lectin domain containing 14A [ Homo sapiens (human) ]

    Gene ID: 161198, updated on 2-Oct-2018

    Summary

    Official Symbol
    CLEC14Aprovided by HGNC
    Official Full Name
    C-type lectin domain containing 14Aprovided by HGNC
    Primary source
    HGNC:HGNC:19832
    See related
    Ensembl:ENSG00000176435 MIM:616845; Vega:OTTHUMG00000140248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEG1; EGFR-5; C14orf27
    Summary
    This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]
    Orthologs

    Genomic context

    See CLEC14A in Genome Data Viewer
    Location:
    14q21.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (38254000..38256370, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (38723205..38725575, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370456 Neighboring gene uncharacterized LOC112268136 Neighboring gene somatostatin receptor 1 Neighboring gene general transcription factor IIH subunit 3 pseudogene Neighboring gene keratin 8 pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular matrix protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    collagen-containing extracellular matrix HDA PubMed 
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    C-type lectin domain family 14 member A
    Names
    ClECT and EGF-like domain containing protein
    epidermal growth factor receptor 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175060.2NP_778230.1  C-type lectin domain family 14 member A precursor

      See identical proteins and their annotated locations for NP_778230.1

      Status: REVIEWED

      Source sequence(s)
      AY358395, AY606132, BX423057
      Consensus CDS
      CCDS9667.1
      UniProtKB/Swiss-Prot
      Q86T13
      Related
      ENSP00000353013.2, OTTHUMP00000178873, ENST00000342213.2, OTTHUMT00000276729
      Conserved Domains (2) summary
      cd03600
      Location:32175
      CLECT_thrombomodulin_like; C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR
      pfam14670
      Location:254286
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      38254000..38256370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center