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    DGKA diacylglycerol kinase alpha [ Homo sapiens (human) ]

    Gene ID: 1606, updated on 3-Oct-2018

    Summary

    Official Symbol
    DGKAprovided by HGNC
    Official Full Name
    diacylglycerol kinase alphaprovided by HGNC
    Primary source
    HGNC:HGNC:2849
    See related
    Ensembl:ENSG00000065357 MIM:125855; Vega:OTTHUMG00000170109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAGK; DAGK1; DGK-alpha
    Summary
    The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]
    Expression
    Broad expression in lymph node (RPKM 36.2), skin (RPKM 31.7) and 19 other tissues See more
    Orthologs

    Genomic context

    See DGKA in Genome Data Viewer
    Location:
    12q13.2
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (55931091..55954023)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56324946..56347811)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase pi 1 pseudogene 1 Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC12821, MGC42356

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    diacylglycerol kinase activity TAS
    Traceable Author Statement
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diacylglycerol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycerolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycerolipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    lipid phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet activation TAS
    Traceable Author Statement
    more info
     
    protein kinase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    diacylglycerol kinase alpha
    Names
    80 kDa diacylglycerol kinase
    DAG kinase alpha
    diacylglycerol kinase, alpha 80kDa
    diglyceride kinase alpha
    NP_001336.2
    NP_001337962.1
    NP_001337963.1
    NP_001337964.1
    NP_001337965.1
    NP_001337966.1
    NP_001337967.1
    NP_001337968.1
    NP_001337969.1
    NP_958852.1
    NP_958853.1
    NP_963848.1
    XP_005268746.1
    XP_011536295.1
    XP_011536297.1
    XP_016874389.1
    XP_016874390.1
    XP_016874391.1
    XP_016874392.1
    XP_016874393.1
    XP_016874394.1
    XP_016874395.1
    XP_016874396.1
    XP_016874397.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001345.4NP_001336.2  diacylglycerol kinase alpha isoform a

      See identical proteins and their annotated locations for NP_001336.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 1, 2, and 4-6, encodes isoform a.
      Source sequence(s)
      AF064768, BC023523, BC031870, BM836118, BQ943057
      Consensus CDS
      CCDS8896.1
      UniProtKB/Swiss-Prot
      P23743
      UniProtKB/TrEMBL
      A0A024RB23
      Related
      ENSP00000328405.5, OTTHUMP00000242836, ENST00000331886.9, OTTHUMT00000407291
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    2. NM_001351033.1NP_001337962.1  diacylglycerol kinase alpha isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1-4 and 6, encodes isoform a.
      Source sequence(s)
      AC025162, BC031870
      Consensus CDS
      CCDS8896.1
      Related
      ENSP00000450359.1, ENST00000551156.5
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    3. NM_001351034.1NP_001337963.1  diacylglycerol kinase alpha isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1-5, encodes isoform a.
      Source sequence(s)
      AC025162
      Consensus CDS
      CCDS8896.1
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    4. NM_001351035.1NP_001337964.1  diacylglycerol kinase alpha isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes the longest isoform (b).
      Source sequence(s)
      AC025162
      Conserved Domains (5) summary
      smart00045
      Location:558739
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:416537
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:152221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:244292
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:44148
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    5. NM_001351036.1NP_001337965.1  diacylglycerol kinase alpha isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes isoform c.
      Source sequence(s)
      AC025162
      Conserved Domains (4) summary
      smart00045
      Location:379560
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:237358
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:65113
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl08302
      Location:142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    6. NM_001351037.1NP_001337966.1  diacylglycerol kinase alpha isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 8, encodes isoform c.
      Source sequence(s)
      AC025162
      Conserved Domains (4) summary
      smart00045
      Location:379560
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:237358
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:65113
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl08302
      Location:142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    7. NM_001351038.1NP_001337967.1  diacylglycerol kinase alpha isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 11 and 12, encodes isoform d.
      Source sequence(s)
      AC025162
      Conserved Domains (2) summary
      smart00045
      Location:166347
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:24145
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    8. NM_001351039.1NP_001337968.1  diacylglycerol kinase alpha isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 10 and 12, encodes isoform d.
      Source sequence(s)
      AC025162
      Conserved Domains (2) summary
      smart00045
      Location:166347
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:24145
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    9. NM_001351040.1NP_001337969.1  diacylglycerol kinase alpha isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 10 and 11, encodes isoform d.
      Source sequence(s)
      AC025162
      Conserved Domains (2) summary
      smart00045
      Location:166347
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:24145
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    10. NM_201444.2NP_958852.1  diacylglycerol kinase alpha isoform a

      See identical proteins and their annotated locations for NP_958852.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 2-6, encodes isoform a.
      Source sequence(s)
      AF064768, AI815678, BC023523, BC031870, BM910598
      Consensus CDS
      CCDS8896.1
      UniProtKB/Swiss-Prot
      P23743
      UniProtKB/TrEMBL
      A0A024RB23
      Related
      ENSP00000377703.1, ENST00000394147.5
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    11. NM_201445.1NP_958853.1  diacylglycerol kinase alpha isoform a

      See identical proteins and their annotated locations for NP_958853.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3-6, encodes isoform a.
      Source sequence(s)
      AF064768, BC023523, BC031870, BF448612
      Consensus CDS
      CCDS8896.1
      UniProtKB/Swiss-Prot
      P23743
      UniProtKB/TrEMBL
      A0A024RB23
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    12. NM_201554.1NP_963848.1  diacylglycerol kinase alpha isoform a

      See identical proteins and their annotated locations for NP_963848.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 1-3, 5, and 6, encodes isoform a.
      Source sequence(s)
      AF064768, BC023523, BC031870, BF448612
      Consensus CDS
      CCDS8896.1
      UniProtKB/Swiss-Prot
      P23743
      UniProtKB/TrEMBL
      A0A024RB23
      Related
      OTTHUMP00000242955, OTTHUMT00000407456
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6110
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    RNA

    1. NR_147026.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC025162
      Related
      ENST00000402956.7
    2. NR_147027.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC025162

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      55931091..55954023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018901.2XP_016874390.1  diacylglycerol kinase alpha isoform X2

    2. XM_011537993.2XP_011536295.1  diacylglycerol kinase alpha isoform X4

      See identical proteins and their annotated locations for XP_011536295.1

      UniProtKB/Swiss-Prot
      P23743
      UniProtKB/TrEMBL
      A0A024RB23
      Conserved Domains (5) summary
      smart00045
      Location:520701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6110
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    3. XM_011537995.2XP_011536297.1  diacylglycerol kinase alpha isoform X5

      See identical proteins and their annotated locations for XP_011536297.1

      Conserved Domains (4) summary
      smart00045
      Location:408589
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:266387
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:94142
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl08302
      Location:3071
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    4. XM_017018907.1XP_016874396.1  diacylglycerol kinase alpha isoform X2

    5. XM_017018902.1XP_016874391.1  diacylglycerol kinase alpha isoform X2

    6. XM_017018903.1XP_016874392.1  diacylglycerol kinase alpha isoform X2

    7. XM_017018906.2XP_016874395.1  diacylglycerol kinase alpha isoform X2

    8. XM_017018904.1XP_016874393.1  diacylglycerol kinase alpha isoform X2

    9. XM_005268689.2XP_005268746.1  diacylglycerol kinase alpha isoform X5

      See identical proteins and their annotated locations for XP_005268746.1

      Conserved Domains (4) summary
      smart00045
      Location:408589
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:266387
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:94142
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl08302
      Location:3071
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    10. XM_017018905.1XP_016874394.1  diacylglycerol kinase alpha isoform X2

    11. XM_017018900.1XP_016874389.1  diacylglycerol kinase alpha isoform X1

    12. XM_017018908.1XP_016874397.1  diacylglycerol kinase alpha isoform X3

    RNA

    1. XR_002957296.1 RNA Sequence

    2. XR_002957293.1 RNA Sequence

    3. XR_001748602.1 RNA Sequence

    4. XR_002957294.1 RNA Sequence

    5. XR_002957295.1 RNA Sequence

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