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    Cldn16 claudin 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 155268, updated on 7-Oct-2018

    Summary

    Official Symbol
    Cldn16provided by RGD
    Official Full Name
    claudin 16provided by RGD
    Primary source
    RGD:620322
    See related
    Ensembl:ENSRNOG00000055138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pcln1
    Summary
    renal tight junction protein; involved in paracellular transport of magnesium and calcium [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 159.7) See more
    Orthologs

    Genomic context

    See Cldn16 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (77683942..77703232, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (83013610..83035155)

    Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein Neighboring gene uncharacterized LOC103690593 Neighboring gene transmembrane protein 207 Neighboring gene similar to poly(A) binding protein, cytoplasmic 4 isoform 2 Neighboring gene claudin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transepithelial transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bicellular tight junction TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    claudin-16
    Names
    paracellin-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131905.2NP_571980.2  claudin-16

      See identical proteins and their annotated locations for NP_571980.2

      Status: VALIDATED

      Source sequence(s)
      AC125303
      UniProtKB/TrEMBL
      A0A0G2K8J2
      Related
      ENSRNOP00000074628.1, ENSRNOT00000083319.1
      Conserved Domains (1) summary
      cl21598
      Location:11183
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

      Range
      77683942..77703232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000079.1 Alternate Rn_Celera

      Range
      73208029..73227202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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