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    Hipk2 homeodomain interacting protein kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 15258, updated on 2-Oct-2018

    Summary

    Official Symbol
    Hipk2provided by MGI
    Official Full Name
    homeodomain interacting protein kinase 2provided by MGI
    Primary source
    MGI:MGI:1314872
    See related
    Ensembl:ENSMUSG00000061436 Vega:OTTMUSG00000034370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stank; 1110014O20Rik; B230339E18Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 22.0), subcutaneous fat pad adult (RPKM 17.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hipk2 in Genome Data Viewer
    Location:
    6; 6 B1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (38687512..38876190, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (38647839..38826189, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor subfamily G, member 2 Neighboring gene C-type lectin domain family 2, member L Neighboring gene predicted gene, 38496 Neighboring gene RIKEN cDNA 4930502C15 gene Neighboring gene predicted gene, 46988 Neighboring gene thromboxane A synthase 1, platelet Neighboring gene predicted gene, 33767 Neighboring gene predicted gene, 38688

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    virion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    iris morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lens induction in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voluntary musculoskeletal movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with PML body ISO
    Inferred from Sequence Orthology
    more info
     
    PML body TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA polymerase II transcription factor complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    homeodomain-interacting protein kinase 2
    Names
    nuclear body-associated kinase 1
    sialophorin tail-associated nuclear serine/threonine-protein kinase
    NP_001129537.1
    NP_001281072.1
    NP_001281073.1
    NP_034563.2
    XP_006505665.1
    XP_006505666.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136065.2NP_001129537.1  homeodomain-interacting protein kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_001129537.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has multiple differences compared to variant 2. These differences result in a distinct 5' UTR, and cause translation initiation at a downstream start codon, compared to variant 2. The encoded isoform (1) is shorter than isoform 2.
      Source sequence(s)
      AF208292, AK016742, BM122543
      Consensus CDS
      CCDS51752.1
      UniProtKB/Swiss-Prot
      Q9QZR5
      UniProtKB/TrEMBL
      A0A0R4J204
      Related
      ENSMUSP00000125572.1, OTTMUSP00000047444, ENSMUST00000160962.7, OTTMUST00000087375
      Conserved Domains (2) summary
      smart00220
      Location:192520
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:176530
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    2. NM_001294143.1NP_001281072.1  homeodomain-interacting protein kinase 2 isoform 3

      See identical proteins and their annotated locations for NP_001281072.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region compared to variant 2. The encoded isoform (3) is shorter than isoform 2.
      Source sequence(s)
      AC154016, AF170301, BM122543
      Consensus CDS
      CCDS80527.1
      UniProtKB/Swiss-Prot
      Q9QZR5
      UniProtKB/TrEMBL
      Q5D0E9
      Related
      ENSMUSP00000125150.1, OTTMUSP00000047472, ENSMUST00000162359.7, OTTMUST00000087403
      Conserved Domains (2) summary
      smart00220
      Location:199527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    3. NM_001294144.1NP_001281073.1  homeodomain-interacting protein kinase 2 isoform 4

      See identical proteins and their annotated locations for NP_001281073.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses two alternate in-frame splice sites in the coding region compared to variant 2. The encoded isoform (4) is shorter than isoform 2.
      Source sequence(s)
      AC118613, AC154016, AC161147
      Consensus CDS
      CCDS80526.1
      UniProtKB/Swiss-Prot
      Q9QZR5
      UniProtKB/TrEMBL
      A0A0R4J202
      Related
      ENSMUSP00000125500.1, OTTMUSP00000047471, ENSMUST00000160360.1, OTTMUST00000087402
      Conserved Domains (2) summary
      smart00220
      Location:199527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    4. NM_010433.2NP_034563.2  homeodomain-interacting protein kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_034563.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AC154016, AF170302, BM122543
      Consensus CDS
      CCDS20017.2
      UniProtKB/Swiss-Prot
      Q9QZR5
      Related
      ENSMUSP00000124133.1, OTTMUSP00000047473, ENSMUST00000161779.7, OTTMUST00000087404
      Conserved Domains (2) summary
      smart00220
      Location:199527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      38687512..38876190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505602.3XP_006505665.1  homeodomain-interacting protein kinase 2 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:199527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    2. XM_006505603.3XP_006505666.1  homeodomain-interacting protein kinase 2 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:192520
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:176530
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    RNA

    1. XR_001785097.1 RNA Sequence

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