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    Gpr19 G protein-coupled receptor 19 [ Mus musculus (house mouse) ]

    Gene ID: 14760, updated on 18-Sep-2018

    Summary

    Official Symbol
    Gpr19provided by MGI
    Official Full Name
    G protein-coupled receptor 19provided by MGI
    Primary source
    MGI:MGI:892973
    See related
    Ensembl:ENSMUSG00000032641 Vega:OTTMUSG00000024355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in testis adult (RPKM 6.5), whole brain E14.5 (RPKM 5.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gpr19 in Genome Data Viewer
    Location:
    6; 6 G1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (134869092..134899482, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (134819111..134847943, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700055D16 gene Neighboring gene cAMP responsive element binding protein-like 2 Neighboring gene RIKEN cDNA 2810454H06 gene Neighboring gene predicted gene, 40407 Neighboring gene cyclin-dependent kinase inhibitor 1B Neighboring gene lncRNA downstream of Cdkn1b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    probable G-protein coupled receptor 19

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167694.2NP_001161166.1  probable G-protein coupled receptor 19 isoform a

      See identical proteins and their annotated locations for NP_001161166.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longer isoform (a). Variants 3, 6 and 7 all encode isoform a.
      Source sequence(s)
      AC122193, AK140770, BY712856, DV660907
      Consensus CDS
      CCDS51937.1
      UniProtKB/Swiss-Prot
      Q61121
      Related
      ENSMUSP00000047630.7, OTTMUSP00000029039, ENSMUST00000046255.13, OTTMUST00000059660
      Conserved Domains (2) summary
      pfam00001
      Location:82330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:72258
      7tm_4; Olfactory receptor
    2. NM_001167695.2NP_001161167.1  probable G-protein coupled receptor 19 isoform b

      See identical proteins and their annotated locations for NP_001161167.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.
      Source sequence(s)
      AC122193, AK140770
      Consensus CDS
      CCDS20641.1
      UniProtKB/Swiss-Prot
      Q61121
      Conserved Domains (1) summary
      cd15008
      Location:61335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001167696.2NP_001161168.1  probable G-protein coupled receptor 19 isoform b

      See identical proteins and their annotated locations for NP_001161168.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.
      Source sequence(s)
      AC122193, AK132917, DV651999
      Consensus CDS
      CCDS20641.1
      UniProtKB/Swiss-Prot
      Q61121
      Related
      ENSMUSP00000127876.1, ENSMUST00000165392.7
      Conserved Domains (1) summary
      cd15008
      Location:61335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001167697.2NP_001161169.1  probable G-protein coupled receptor 19 isoform a

      See identical proteins and their annotated locations for NP_001161169.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 3. Variants 3, 6 and 7 all encode isoform a.
      Source sequence(s)
      AC122193, AK132917, BB853775, BQ558507
      Consensus CDS
      CCDS51937.1
      UniProtKB/Swiss-Prot
      Q61121
      Conserved Domains (2) summary
      pfam00001
      Location:82330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:72258
      7tm_4; Olfactory receptor
    5. NM_001167699.2NP_001161171.1  probable G-protein coupled receptor 19 isoform a

      See identical proteins and their annotated locations for NP_001161171.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 3. Variants 3, 6 and 7 all encode isoform a.
      Source sequence(s)
      AC122193, AK132917, BB853775, BQ558507, BY275399, BY291247
      Consensus CDS
      CCDS51937.1
      UniProtKB/Swiss-Prot
      Q61121
      Conserved Domains (2) summary
      pfam00001
      Location:82330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:72258
      7tm_4; Olfactory receptor
    6. NM_001167700.2NP_001161172.1  probable G-protein coupled receptor 19 isoform b

      See identical proteins and their annotated locations for NP_001161172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.
      Source sequence(s)
      AC122193, AK132917, BY712856
      Consensus CDS
      CCDS20641.1
      UniProtKB/Swiss-Prot
      Q61121
      Related
      ENSMUSP00000107563.1, OTTMUSP00000029038, ENSMUST00000111932.7, OTTMUST00000059659
      Conserved Domains (1) summary
      cd15008
      Location:61335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
    7. NM_001362048.1NP_001348977.1  probable G-protein coupled receptor 19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variants 2, 4, 5, and 8-12, encodes isoform b.
      Source sequence(s)
      AC122193
      Conserved Domains (1) summary
      cd15008
      Location:61335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
    8. NM_001362049.1NP_001348978.1  probable G-protein coupled receptor 19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 2, 4, 5, 8, and 10-12, encodes isoform b.
      Source sequence(s)
      AC122193
      Conserved Domains (1) summary
      cd15008
      Location:61335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
    9. NM_001362050.1NP_001348979.1  probable G-protein coupled receptor 19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 2, 4, 5, 8, 9, 11, and 12, encodes the same isoform (b).
      Source sequence(s)
      AC122193
      Conserved Domains (1) summary
      cd15008
      Location:61335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
    10. NM_001362051.1NP_001348980.1  probable G-protein coupled receptor 19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 1, 2, 4, 5, 8-10, and 12, encodes isoform b.
      Source sequence(s)
      AC122193
      Conserved Domains (1) summary
      cd15008
      Location:61335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
    11. NM_001362052.1NP_001348981.1  probable G-protein coupled receptor 19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 1, 2, 4, 5, and 8-11, encodes isoform b.
      Source sequence(s)
      AC122193
      Conserved Domains (1) summary
      cd15008
      Location:61335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
    12. NM_008157.3NP_032183.2  probable G-protein coupled receptor 19 isoform b

      See identical proteins and their annotated locations for NP_032183.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.
      Source sequence(s)
      AC122193, AK132917, BB853775, BY275399
      Consensus CDS
      CCDS20641.1
      UniProtKB/Swiss-Prot
      Q61121
      Conserved Domains (1) summary
      cd15008
      Location:61335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. NR_155270.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122193, BY712856

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      134869092..134899482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505547.3XP_006505610.1  probable G-protein coupled receptor 19 isoform X1

      See identical proteins and their annotated locations for XP_006505610.1

      UniProtKB/TrEMBL
      A0A1N9MDH9
      Conserved Domains (2) summary
      pfam00001
      Location:168416
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:158344
      7tm_4; Olfactory receptor
    2. XM_006505544.3XP_006505607.1  probable G-protein coupled receptor 19 isoform X1

      See identical proteins and their annotated locations for XP_006505607.1

      UniProtKB/TrEMBL
      A0A1N9MDH9
      Conserved Domains (2) summary
      pfam00001
      Location:168416
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:158344
      7tm_4; Olfactory receptor
    3. XM_006505543.3XP_006505606.1  probable G-protein coupled receptor 19 isoform X1

      See identical proteins and their annotated locations for XP_006505606.1

      UniProtKB/TrEMBL
      A0A1N9MDH9
      Conserved Domains (2) summary
      pfam00001
      Location:168416
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:158344
      7tm_4; Olfactory receptor
    4. XM_006505545.2XP_006505608.1  probable G-protein coupled receptor 19 isoform X1

      See identical proteins and their annotated locations for XP_006505608.1

      UniProtKB/TrEMBL
      A0A1N9MDH9
      Conserved Domains (2) summary
      pfam00001
      Location:168416
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:158344
      7tm_4; Olfactory receptor
    5. XM_006505554.1XP_006505617.1  probable G-protein coupled receptor 19 isoform X3

      UniProtKB/Swiss-Prot
      Q61121
      Related
      ENSMUSP00000112214.2, ENSMUST00000116515.8
      Conserved Domains (1) summary
      cd15008
      Location:61335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
    6. XM_017321391.1XP_017176880.1  probable G-protein coupled receptor 19 isoform X2

    7. XM_017321392.1XP_017176881.1  probable G-protein coupled receptor 19 isoform X2

    8. XM_017321393.1XP_017176882.1  probable G-protein coupled receptor 19 isoform X3

      UniProtKB/Swiss-Prot
      Q61121
      Conserved Domains (1) summary
      cd15008
      Location:61335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
    9. XM_017321390.1XP_017176879.1  probable G-protein coupled receptor 19 isoform X1

      UniProtKB/TrEMBL
      A0A1N9MDH9
      Related
      ENSMUSP00000066287.7, OTTMUSP00000029040, ENSMUST00000066107.9, OTTMUST00000059663
      Conserved Domains (2) summary
      pfam00001
      Location:168416
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:158344
      7tm_4; Olfactory receptor

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001167693.1: Suppressed sequence

      Description
      NM_001167693.1: This RefSeq was permanently suppressed because a small upstream ORF with a strong Kozak signal overlaps the expected translation start site, making it unlikely that this transcript is translated.
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