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    CD300LG CD300 molecule like family member g [ Homo sapiens (human) ]

    Gene ID: 146894, updated on 17-Jun-2019

    Summary

    Official Symbol
    CD300LGprovided by HGNC
    Official Full Name
    CD300 molecule like family member gprovided by HGNC
    Primary source
    HGNC:HGNC:30455
    See related
    Ensembl:ENSG00000161649 MIM:610520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLM9; CLM-9; TREM4; TREM-4; NEPMUCIN
    Summary
    Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in fat (RPKM 45.4), placenta (RPKM 12.3) and 3 other tissues See more
    Orthologs

    Genomic context

    See CD300LG in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (43847097..43863639)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41924145..41940997)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene membrane palmitoylated protein 3 Neighboring gene uncharacterized LOC107984979 Neighboring gene uncharacterized LOC107985077 Neighboring gene membrane palmitoylated protein 2 Neighboring gene uncharacterized LOC105371787 Neighboring gene family with sequence similarity 215 member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    multivesicular body membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    CMRF35-like molecule 9
    Names
    CD300 antigen-like family member G
    triggering receptor expressed on myeloid cells 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168322.2NP_001161794.1  CMRF35-like molecule 9 isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      AK309938
      Consensus CDS
      CCDS54131.1
      UniProtKB/Swiss-Prot
      Q6UXG3
      Related
      ENSP00000442368.1, ENST00000539718.5
      Conserved Domains (2) summary
      cd05716
      Location:24113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22124
      IG_like; Immunoglobulin like
    2. NM_001168323.2NP_001161795.1  CMRF35-like molecule 9 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC015937, AK298112, AK309938
      Consensus CDS
      CCDS54132.1
      UniProtKB/Swiss-Prot
      Q6UXG3
      Related
      ENSP00000366408.3, ENST00000377203.8
      Conserved Domains (2) summary
      cd05716
      Location:24113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22124
      IG_like; Immunoglobulin like
    3. NM_001168324.2NP_001161796.1  CMRF35-like molecule 9 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001161796.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC015937, AF427619
      Consensus CDS
      CCDS54133.1
      UniProtKB/Swiss-Prot
      Q6UXG3
      Related
      ENSP00000293396.7, ENST00000293396.12
      Conserved Domains (2) summary
      cd05716
      Location:24113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22124
      IG_like; Immunoglobulin like
    4. NM_145273.4NP_660316.2  CMRF35-like molecule 9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_660316.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC007993, AC015937, AK298112, AY358364, BC025395
      Consensus CDS
      CCDS11470.1
      UniProtKB/Swiss-Prot
      Q6UXG3
      Related
      ENSP00000321005.3, ENST00000317310.5
      Conserved Domains (2) summary
      cd05716
      Location:24113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22124
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      43847097..43863639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721721.3XP_006721784.1  CMRF35-like molecule 9 isoform X1

      Conserved Domains (2) summary
      cd05716
      Location:24113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22124
      IG_like; Immunoglobulin like
    2. XM_011524384.3XP_011522686.1  CMRF35-like molecule 9 isoform X4

      Conserved Domains (2) summary
      cd05716
      Location:24113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22124
      IG_like; Immunoglobulin like
    3. XM_006721722.3XP_006721785.1  CMRF35-like molecule 9 isoform X2

      Conserved Domains (2) summary
      cd05716
      Location:24113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22124
      IG_like; Immunoglobulin like
    4. XM_005257075.3XP_005257132.1  CMRF35-like molecule 9 isoform X3

      Conserved Domains (2) summary
      cd05716
      Location:24113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22124
      IG_like; Immunoglobulin like
    5. XM_005257076.3XP_005257133.1  CMRF35-like molecule 9 isoform X5

      Conserved Domains (2) summary
      cd05716
      Location:24113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22124
      IG_like; Immunoglobulin like
    6. XM_017024235.2XP_016879724.1  CMRF35-like molecule 9 isoform X6

    RNA

    1. XR_243636.3 RNA Sequence

    2. XR_243637.3 RNA Sequence

    3. XR_243638.3 RNA Sequence

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