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    RTN4RL1 reticulon 4 receptor like 1 [ Homo sapiens (human) ]

    Gene ID: 146760, updated on 14-Oct-2019

    Summary

    Official Symbol
    RTN4RL1provided by HGNC
    Official Full Name
    reticulon 4 receptor like 1provided by HGNC
    Primary source
    HGNC:HGNC:21329
    See related
    Ensembl:ENSG00000185924 MIM:610461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NgR3; NGRH2
    Expression
    Broad expression in brain (RPKM 5.0), fat (RPKM 3.0) and 14 other tissues See more
    Orthologs

    Genomic context

    See RTN4RL1 in Genome Data Viewer
    Location:
    17p13.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (1934677..2025334, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1837971..1928178, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4981 Neighboring gene SET and MYND domain containing 4 Neighboring gene replication protein A1 Neighboring gene succinate dehydrogenase complex subunit C pseudogene Neighboring gene uncharacterized LOC105371486 Neighboring gene uncharacterized LOC105371485 Neighboring gene diphthamide biosynthesis 1 Neighboring gene microRNA 132 Neighboring gene OVCA2 serine hydrolase domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp547J144

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chondroitin sulfate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    axon regeneration TAS
    Traceable Author Statement
    more info
    PubMed 
    corpus callosum development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of axon regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    anchored component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    reticulon-4 receptor-like 1
    Names
    Nogo-66 receptor homolog 2
    Nogo-66 receptor-related protein 3
    nogo receptor-like 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178568.4NP_848663.1  reticulon-4 receptor-like 1 precursor

      See identical proteins and their annotated locations for NP_848663.1

      Status: VALIDATED

      Source sequence(s)
      AC099684, AC130689
      Consensus CDS
      CCDS45569.1
      UniProtKB/Swiss-Prot
      Q86UN2
      Related
      ENSP00000330631.4, ENST00000331238.7
      Conserved Domains (3) summary
      sd00033
      Location:5777
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:174233
      LRR_8; Leucine rich repeat
      cl15307
      Location:255300
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      1934677..2025334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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