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    FBXL16 F-box and leucine rich repeat protein 16 [ Homo sapiens (human) ]

    Gene ID: 146330, updated on 8-Jul-2021

    Summary

    Official Symbol
    FBXL16provided by HGNC
    Official Full Name
    F-box and leucine rich repeat protein 16provided by HGNC
    Primary source
    HGNC:HGNC:14150
    See related
    Ensembl:ENSG00000127585 MIM:609082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fbl16; C16orf22; c380A1.1
    Summary
    Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in brain (RPKM 76.4), testis (RPKM 4.8) and 1 other tissue See more
    Orthologs
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    Genomic context

    See FBXL16 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (692500..707853, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (742500..755801, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene jumonji domain containing 8 Neighboring gene WD repeat domain 24 Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene coiled-coil domain containing 78

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • FLJ33735, MGC33974

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    F-box/LRR-repeat protein 16

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153350.4NP_699181.2  F-box/LRR-repeat protein 16

      See identical proteins and their annotated locations for NP_699181.2

      Status: VALIDATED

      Source sequence(s)
      Z92544, Z97653
      Consensus CDS
      CCDS10421.1
      UniProtKB/Swiss-Prot
      Q8N461
      Related
      ENSP00000380746.1, ENST00000397621.6
      Conserved Domains (2) summary
      sd00034
      Location:220243
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl28166
      Location:201413
      AMN1; Antagonist of mitotic exit network protein 1

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      692500..707853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450160.1XP_024305928.1  F-box/LRR-repeat protein 16 isoform X1

      Conserved Domains (2) summary
      sd00034
      Location:220243
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl28166
      Location:201413
      AMN1; Antagonist of mitotic exit network protein 1
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