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    ASB15 ankyrin repeat and SOCS box containing 15 [ Homo sapiens (human) ]

    Gene ID: 142685, updated on 3-Jun-2018
    Official Symbol
    ASB15provided by HGNC
    Official Full Name
    ankyrin repeat and SOCS box containing 15provided by HGNC
    Primary source
    HGNC:HGNC:19767
    See related
    Ensembl:ENSG00000146809 Vega:OTTHUMG00000157114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
    Expression
    Biased expression in heart (RPKM 6.0), kidney (RPKM 2.1) and 2 other tissues See more
    Orthologs
    See ASB15 in Genome Data Viewer
    Location:
    7q31.32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (123567003..123637900)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (123241882..123277951)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene lysophospholipase I pseudogene 1 Neighboring gene RNA, U6 small nuclear 296, pseudogene Neighboring gene IQ motif and ubiquitin domain containing Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 Neighboring gene uncharacterized LOC102724555 Neighboring gene leiomodin 2 Neighboring gene Wiskott-Aldrich syndrome like

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ43370, DKFZp779M1258

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    ankyrin repeat and SOCS box protein 15

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034019.1 RefSeqGene

      Range
      5001..41031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290258.1NP_001277187.1  ankyrin repeat and SOCS box protein 15

      See identical proteins and their annotated locations for NP_001277187.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC006333, AF403033, AK125360, BC100874, CR749595
      Consensus CDS
      CCDS34742.1
      UniProtKB/Swiss-Prot
      Q8WXK1
      Related
      ENSP00000416433.1, OTTHUMP00000211496, ENST00000451215.5, OTTHUMT00000347495
      Conserved Domains (4) summary
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:115207
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    2. NM_080928.4NP_563616.3  ankyrin repeat and SOCS box protein 15

      See identical proteins and their annotated locations for NP_563616.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC006333, AF403033, AK125360, BC100874, CR749595
      Consensus CDS
      CCDS34742.1
      UniProtKB/Swiss-Prot
      Q8WXK1
      Related
      ENSP00000275699.3, ENST00000275699.4
      Conserved Domains (4) summary
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:115207
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      123567003..123637900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515819.2XP_011514121.1  ankyrin repeat and SOCS box protein 15 isoform X2

      See identical proteins and their annotated locations for XP_011514121.1

      UniProtKB/Swiss-Prot
      Q8WXK1
      Related
      ENSP00000397655.1, OTTHUMP00000211495, ENST00000451558.5, OTTHUMT00000347493
      Conserved Domains (4) summary
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:115207
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    2. XM_017011757.1XP_016867246.1  ankyrin repeat and SOCS box protein 15 isoform X2

      UniProtKB/Swiss-Prot
      Q8WXK1
      Conserved Domains (4) summary
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:115207
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    3. XM_011515817.2XP_011514119.1  ankyrin repeat and SOCS box protein 15 isoform X2

      See identical proteins and their annotated locations for XP_011514119.1

      UniProtKB/Swiss-Prot
      Q8WXK1
      Conserved Domains (4) summary
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:115207
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    4. XM_005250146.4XP_005250203.1  ankyrin repeat and SOCS box protein 15 isoform X2

      See identical proteins and their annotated locations for XP_005250203.1

      UniProtKB/Swiss-Prot
      Q8WXK1
      Conserved Domains (4) summary
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:115207
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    5. XM_024446667.1XP_024302435.1  ankyrin repeat and SOCS box protein 15 isoform X4

      Conserved Domains (3) summary
      cd00204
      Location:125243
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03731
      Location:479534
      SOCS_ASB15; SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of ...
      sd00045
      Location:125154
      ANK; ANK repeat [structural motif]
    6. XM_011515820.2XP_011514122.1  ankyrin repeat and SOCS box protein 15 isoform X2

      See identical proteins and their annotated locations for XP_011514122.1

      UniProtKB/Swiss-Prot
      Q8WXK1
      Conserved Domains (4) summary
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:115207
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    7. XM_011515818.2XP_011514120.1  ankyrin repeat and SOCS box protein 15 isoform X2

      See identical proteins and their annotated locations for XP_011514120.1

      UniProtKB/Swiss-Prot
      Q8WXK1
      Conserved Domains (4) summary
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:115207
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    8. XM_011515816.2XP_011514118.1  ankyrin repeat and SOCS box protein 15 isoform X1

      Conserved Domains (4) summary
      cd00204
      Location:144269
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:121213
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:184213
      ANK; ANK repeat [structural motif]
      cl02533
      Location:538593
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    9. XM_011515821.2XP_011514123.1  ankyrin repeat and SOCS box protein 15 isoform X3

      Conserved Domains (4) summary
      cd00204
      Location:131249
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:135226
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:131160
      ANK; ANK repeat [structural motif]
      cl02533
      Location:485540
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    10. XM_017011756.2XP_016867245.1  ankyrin repeat and SOCS box protein 15 isoform X2

      UniProtKB/Swiss-Prot
      Q8WXK1
      Conserved Domains (4) summary
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:115207
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    11. XM_017011758.1XP_016867247.1  ankyrin repeat and SOCS box protein 15 isoform X5

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