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    Abcb6 ATP binding cassette subfamily B member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140669, updated on 21-Jul-2018

    Summary

    Official Symbol
    Abcb6provided by RGD
    Official Full Name
    ATP binding cassette subfamily B member 6provided by RGD
    Primary source
    RGD:71077
    See related
    Ensembl:ENSRNOG00000018697
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MTABC3
    Summary
    ATP-binding cassette (ABC) half-transporter that together with its dimerization partner alters the localization of toxic substances [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 175.7), Liver (RPKM 158.7) and 9 other tissues See more
    Orthologs

    Genomic context

    See Abcb6 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82373950..82382228, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (82143211..82151489, complement)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene reticulophagy regulator family member 2 Neighboring gene zinc finger AN1-type containing 2B Neighboring gene autophagy related 9A Neighboring gene ankyrin repeat and zinc finger domain containing 1 Neighboring gene galactosidase, beta 1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC93242

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    efflux transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme-transporting ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    heme-transporting ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    brain development ISO
    Inferred from Sequence Orthology
    more info
     
    heme transport IEA
    Inferred from Electronic Annotation
    more info
     
    heme transport ISO
    Inferred from Sequence Orthology
    more info
     
    porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    porphyrin-containing compound biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    skin development IEA
    Inferred from Electronic Annotation
    more info
     
    skin development ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial envelope ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    NOT mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-binding cassette sub-family B member 6, mitochondrial
    Names
    ATP-binding cassette, sub-family B (MDR/TAP), member 6
    ATP-binding cassette, subfamily B (MDR/TAP), member 6
    mammalian mitochondrial ABC protein 3
    ubiquitously-expressed mammalian ABC half transporter

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080582.1NP_542149.1  ATP-binding cassette sub-family B member 6, mitochondrial

      See identical proteins and their annotated locations for NP_542149.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ003004
      UniProtKB/Swiss-Prot
      O70595
      Related
      ENSRNOP00000025627.3, ENSRNOT00000025627.6
      Conserved Domains (4) summary
      cd03253
      Location:590825
      ABCC_ATM1_transporter; ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C
      COG5265
      Location:329823
      ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
      pfam16185
      Location:6255
      MTABC_N; Mitochondrial ABC-transporter N-terminal five TM region
      cl00549
      Location:277544
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      82373950..82382228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      74239003..74247281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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