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    ZFP28 ZFP28 zinc finger protein [ Homo sapiens (human) ]

    Gene ID: 140612, updated on 2-Oct-2018

    Summary

    Official Symbol
    ZFP28provided by HGNC
    Official Full Name
    ZFP28 zinc finger proteinprovided by HGNC
    Primary source
    HGNC:HGNC:17801
    See related
    Ensembl:ENSG00000196867 MIM:616798; Vega:OTTHUMG00000181944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    mkr5
    Expression
    Ubiquitous expression in ovary (RPKM 2.5), brain (RPKM 2.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See ZFP28 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (56536790..56559192)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57050317..57068170)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF667 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105372471 Neighboring gene zinc finger protein 471 Neighboring gene uncharacterized LOC101928982 Neighboring gene uncharacterized LOC112268241 Neighboring gene zinc finger protein 470 Neighboring gene sialic acid binding Ig like lectin 31, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1431, MGC104540, DKFZp686K03205

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 28 homolog
    Names
    krueppel-like zinc finger factor X6
    zfp-28
    zinc finger factor X6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308440.1NP_001295369.1  zinc finger protein 28 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon that extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC005498, AF507045, BC028416
      Consensus CDS
      CCDS77363.1
      UniProtKB/Swiss-Prot
      Q8NHY6
      Related
      ENSP00000468603.1, OTTHUMP00000267956, ENST00000591844.5, OTTHUMT00000458410
      Conserved Domains (2) summary
      smart00349
      Location:103163
      KRAB; krueppel associated box
      pfam01352
      Location:103142
      KRAB; KRAB box
    2. NM_020828.1NP_065879.1  zinc finger protein 28 homolog isoform 1

      See identical proteins and their annotated locations for NP_065879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF507045
      Consensus CDS
      CCDS12946.1
      UniProtKB/Swiss-Prot
      Q8NHY6
      Related
      ENSP00000301318.3, OTTHUMP00000267955, ENST00000301318.7, OTTHUMT00000458409
      Conserved Domains (6) summary
      smart00349
      Location:103163
      KRAB; krueppel associated box
      COG5048
      Location:417806
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:619639
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:420442
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:103142
      KRAB; KRAB box
      pfam13465
      Location:659684
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      56536790..56559192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526463.3XP_011524765.2  zinc finger protein 28 homolog isoform X1

    2. XM_011526462.3XP_011524764.1  zinc finger protein 28 homolog isoform X2

      See identical proteins and their annotated locations for XP_011524764.1

      Conserved Domains (6) summary
      smart00349
      Location:666
      KRAB; krueppel associated box
      COG5048
      Location:320709
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:522542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:323345
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:645
      KRAB; KRAB box
      pfam13465
      Location:562587
      zf-H2C2_2; Zinc-finger double domain
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