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    ASB5 ankyrin repeat and SOCS box containing 5 [ Homo sapiens (human) ]

    Gene ID: 140458, updated on 5-Aug-2018

    Summary

    Official Symbol
    ASB5provided by HGNC
    Official Full Name
    ankyrin repeat and SOCS box containing 5provided by HGNC
    Primary source
    HGNC:HGNC:17180
    See related
    Ensembl:ENSG00000164122 MIM:615050; Vega:OTTHUMG00000160793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASB-5
    Summary
    The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 5.3), urinary bladder (RPKM 4.0) and 6 other tissues See more
    Orthologs

    Genomic context

    See ASB5 in Genome Data Viewer
    Location:
    4q34.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (176213673..176277571, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (177134824..177198722, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 17 Neighboring gene spermatogenesis associated 4 Neighboring gene signal peptidase complex subunit 3 Neighboring gene cutaneous T cell lymphoma-associated antigen 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat and SOCS box protein 5
    Names
    SOCS box protein ASB-5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080874.3NP_543150.1  ankyrin repeat and SOCS box protein 5

      See identical proteins and their annotated locations for NP_543150.1

      Status: REVIEWED

      Source sequence(s)
      AC093605, BX647857
      Consensus CDS
      CCDS3827.1
      UniProtKB/Swiss-Prot
      Q8WWX0
      UniProtKB/TrEMBL
      Q5HYF3
      Related
      ENSP00000296525.3, OTTHUMP00000218996, ENST00000296525.7, OTTHUMT00000362344
      Conserved Domains (3) summary
      cd00204
      Location:71188
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03724
      Location:288329
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:71100
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

      Range
      176213673..176277571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262759.1XP_005262816.1  ankyrin repeat and SOCS box protein 5 isoform X1

      See identical proteins and their annotated locations for XP_005262816.1

      UniProtKB/Swiss-Prot
      Q8WWX0
      UniProtKB/TrEMBL
      Q5HYF3
      Conserved Domains (3) summary
      cd00204
      Location:71188
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03724
      Location:288329
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:71100
      ANK; ANK repeat [structural motif]
    2. XM_011531617.3XP_011529919.1  ankyrin repeat and SOCS box protein 5 isoform X3

      See identical proteins and their annotated locations for XP_011529919.1

      UniProtKB/Swiss-Prot
      Q8WWX0
      Related
      ENSP00000422877.1, OTTHUMP00000218997, ENST00000512254.1
      Conserved Domains (3) summary
      cd00204
      Location:18135
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:1847
      ANK; ANK repeat [structural motif]
      cl02533
      Location:235276
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    3. XM_011531616.2XP_011529918.1  ankyrin repeat and SOCS box protein 5 isoform X2

      See identical proteins and their annotated locations for XP_011529918.1

      Conserved Domains (4) summary
      cd00204
      Location:26143
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03724
      Location:243284
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      pfam12796
      Location:29120
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:2655
      ANK; ANK repeat [structural motif]
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