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    CRIP1 cysteine rich protein 1 [ Homo sapiens (human) ]

    Gene ID: 1396, updated on 23-Sep-2018

    Summary

    Official Symbol
    CRIP1provided by HGNC
    Official Full Name
    cysteine rich protein 1provided by HGNC
    Primary source
    HGNC:HGNC:2360
    See related
    Ensembl:ENSG00000213145 MIM:123875; Vega:OTTHUMG00000029908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRHP; CRIP; CRP1; CRP-1
    Summary
    Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in small intestine (RPKM 154.6), lung (RPKM 120.1) and 20 other tissues See more
    Orthologs

    Genomic context

    See CRIP1 in Genome Data Viewer
    Location:
    14q32.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (105486920..105488789)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105952892..105955128)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene metastasis associated 1 Neighboring gene cysteine rich protein 2 Neighboring gene tubulin epsilon and delta complex 1 Neighboring gene transmembrane protein 121

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ40971

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    AT DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to UV-B IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to antibiotic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heart development TAS
    Traceable Author Statement
    more info
    PubMed 
    immune response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prostate gland stromal morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    regulation of gene expression IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to zinc ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cysteine-rich protein 1
    Names
    cysteine-rich heart protein
    cysteine-rich intestinal protein
    cysteine-rich protein 1 (intestinal)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311.4NP_001302.1  cysteine-rich protein 1

      See identical proteins and their annotated locations for NP_001302.1

      Status: VALIDATED

      Source sequence(s)
      BC002738, BQ128075, BU500642
      Consensus CDS
      CCDS10004.1
      UniProtKB/Swiss-Prot
      P50238
      Related
      ENSP00000376315.3, OTTHUMP00000163906, ENST00000392531.3, OTTHUMT00000074603
      Conserved Domains (1) summary
      cd09478
      Location:457
      LIM_CRIP; The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      105486920..105488789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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