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    Epb42 erythrocyte membrane protein band 4.2 [ Mus musculus (house mouse) ]

    Gene ID: 13828, updated on 5-Aug-2018

    Summary

    Official Symbol
    Epb42provided by MGI
    Official Full Name
    erythrocyte membrane protein band 4.2provided by MGI
    Primary source
    MGI:MGI:95402
    See related
    Ensembl:ENSMUSG00000023216 Vega:OTTMUSG00000015964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Epb4.2
    Summary
    The protein encoded by this gene is the key component of a macromolecular complex involved in the structure of erythrocytes. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in liver E14.5 (RPKM 57.9), liver E14 (RPKM 55.2) and 3 other tissues See more
    Orthologs

    Genomic context

    See Epb42 in Genome Data Viewer
    Location:
    2 E5; 2 60.37 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (121017891..121036877, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (120843953..120862491, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 62 Neighboring gene U3B small nuclear RNA pseudogene 2 Neighboring gene cyclin D-type binding-protein 1 Neighboring gene WW domain binding protein 2 pseudogene Neighboring gene transglutaminase 5 Neighboring gene transglutaminase 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein-glutamine gamma-glutamyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrocyte maturation IEA
    Inferred from Electronic Annotation
    more info
     
    hemoglobin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptide cross-linking IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    erythrocyte membrane protein band 4.2
    Names
    P4.2
    erythrocyte protein 4.2
    erythrocyte protein band 4.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013513.3NP_038541.1  erythrocyte membrane protein band 4.2

      See identical proteins and their annotated locations for NP_038541.1

      Status: REVIEWED

      Source sequence(s)
      AK133896, AK143841, BY230962
      Consensus CDS
      CCDS16631.1
      UniProtKB/Swiss-Prot
      P49222
      Related
      ENSMUSP00000099548.3, OTTMUSP00000017032, ENSMUST00000102490.9, OTTMUST00000037960
      Conserved Domains (3) summary
      smart00460
      Location:261351
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:6123
      Transglut_N; Transglutaminase family
      pfam00927
      Location:588686
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      121017891..121036877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498727.3XP_006498790.1  erythrocyte membrane protein band 4.2 isoform X1

      Conserved Domains (3) summary
      smart00460
      Location:261351
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:6123
      Transglut_N; Transglutaminase family
      pfam00927
      Location:588686
      Transglut_C; Transglutaminase family, C-terminal ig like domain
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