Format

Send to:

Choose Destination
    • Showing Current items.

    CRABP1 cellular retinoic acid binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 1381, updated on 5-Jul-2021

    Summary

    Official Symbol
    CRABP1provided by HGNC
    Official Full Name
    cellular retinoic acid binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:2338
    See related
    Ensembl:ENSG00000166426 MIM:180230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RBP5; CRABP; CRABPI; CRABP-I
    Summary
    This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in thyroid (RPKM 65.7), spleen (RPKM 23.2) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CRABP1 in Genome Data Viewer
    Location:
    15q25.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (78340353..78348225)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78632695..78640567)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370910 Neighboring gene DnaJ heat shock protein family (Hsp40) member A4 Neighboring gene WD repeat domain 61 Neighboring gene RWD domain containing 1 pseudogene 1 Neighboring gene uncharacterized LOC105370912

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinoic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinoid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables retinol binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in multicellular organism development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in retinoic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    cellular retinoic acid-binding protein 1
    Names
    cellular retinoic acid-binding protein I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004378.3NP_004369.1  cellular retinoic acid-binding protein 1

      See identical proteins and their annotated locations for NP_004369.1

      Status: REVIEWED

      Source sequence(s)
      AI863257, AU132726, BC022069
      Consensus CDS
      CCDS10301.1
      UniProtKB/Swiss-Prot
      P29762
      UniProtKB/TrEMBL
      F1T0F7
      Related
      ENSP00000299529.6, ENST00000299529.7
      Conserved Domains (1) summary
      cd19460
      Location:2137
      CRABP1; cellular retinoic acid-binding protein 1

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      78340353..78348225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center