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    Dyrk1b dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [ Mus musculus (house mouse) ]

    Gene ID: 13549, updated on 4-Jul-2019

    Summary

    Official Symbol
    Dyrk1bprovided by MGI
    Official Full Name
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1bprovided by MGI
    Primary source
    MGI:MGI:1330302
    See related
    Ensembl:ENSMUSG00000002409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mirk
    Expression
    Ubiquitous expression in testis adult (RPKM 39.4), thymus adult (RPKM 16.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See Dyrk1b in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (28179483..28197910)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (28964502..28972313)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31024 Neighboring gene fibrillarin Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene leucine twenty homeobox

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 1B
    NP_001033046.1
    NP_001258299.1
    NP_034222.1
    XP_006539589.1
    XP_006539590.1
    XP_006539591.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037957.3NP_001033046.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69

      See identical proteins and their annotated locations for NP_001033046.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform p69, also known as isoform b.
      Source sequence(s)
      AC141883
      Consensus CDS
      CCDS21037.1
      UniProtKB/Swiss-Prot
      Q9Z188
      Related
      ENSMUSP00000083064.6, ENSMUST00000085901.12
      Conserved Domains (2) summary
      smart00220
      Location:111431
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:97436
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    2. NM_001271370.1NP_001258299.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p75

      See identical proteins and their annotated locations for NP_001258299.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), uses an alternate 5' structure, compared to variant 1. This difference causes translation initiation at an upstream AUG and results in an isoform (p75), also known as isoform c, that has a longer N-terminus, compared to isoform p69.
      Source sequence(s)
      AC141883, AJ537610
      Consensus CDS
      CCDS85251.1
      UniProtKB/Swiss-Prot
      Q9Z188
      Related
      ENSMUSP00000133431.2, ENSMUST00000172467.7
      Conserved Domains (2) summary
      smart00220
      Location:171491
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:157496
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    3. NM_010092.2NP_034222.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65

      See identical proteins and their annotated locations for NP_034222.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform p65, also known as isoform a, which is shorter than isoform p69.
      Source sequence(s)
      AC141883, BX632885, CF104460, Y18280
      Consensus CDS
      CCDS57532.1
      UniProtKB/Swiss-Prot
      Q9Z188
      Related
      ENSMUSP00000133719.1, ENSMUST00000172761.7
      Conserved Domains (2) summary
      smart00220
      Location:111391
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:97396
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      28179483..28197910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539528.3XP_006539591.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

      Conserved Domains (3) summary
      smart00220
      Location:171327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12764
      Location:671
      Gly-rich_Ago1; Glycine-rich region of argonaut
      cl21453
      Location:157329
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006539526.3XP_006539589.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:171463
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:157468
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    3. XM_006539527.3XP_006539590.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:171451
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:157456
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
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