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    ZFAND2B zinc finger AN1-type containing 2B [ Homo sapiens (human) ]

    Gene ID: 130617, updated on 11-Jun-2021

    Summary

    Official Symbol
    ZFAND2Bprovided by HGNC
    Official Full Name
    zinc finger AN1-type containing 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:25206
    See related
    Ensembl:ENSG00000158552 MIM:613474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIRAPL
    Summary
    This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
    Expression
    Ubiquitous expression in thyroid (RPKM 23.0), duodenum (RPKM 18.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZFAND2B in Genome Data Viewer
    Location:
    2q35
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (219206782..219209648)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220071504..220074370)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 23 member 3 Neighboring gene cyclin Pas1/PHO80 domain containing 1 Neighboring gene reticulophagy regulator family member 2 Neighboring gene ATP binding cassette subfamily B member 6 (Langereis blood group) Neighboring gene autophagy related 9A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K48-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in anchored component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    AN1-type zinc finger protein 2B
    Names
    AIRAP-like protein
    arsenite-inducible RNA-associated protein-like protein
    zinc finger, AN1-type domain 2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270998.2NP_001257927.1  AN1-type zinc finger protein 2B isoform 1

      See identical proteins and their annotated locations for NP_001257927.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC068946, BC018415, BM852092, BU195818
      Consensus CDS
      CCDS2435.1
      UniProtKB/Swiss-Prot
      Q8WV99
      UniProtKB/TrEMBL
      A0A024R435
      Related
      ENSP00000411334.3, ENST00000444522.6
      Conserved Domains (3) summary
      pfam01428
      Location:100136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:197212
      UIM; Ubiquitin interaction motif
      pfam06012
      Location:139244
      DUF908; Domain of Unknown Function (DUF908)
    2. NM_001270999.2NP_001257928.1  AN1-type zinc finger protein 2B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC068946, BC018415, BE742808, BM852092
      Consensus CDS
      CCDS74656.1
      UniProtKB/Swiss-Prot
      Q8WV99
      UniProtKB/TrEMBL
      A0A087X0D9
      Related
      ENSP00000483320.1, ENST00000621130.4
      Conserved Domains (2) summary
      pfam01428
      Location:5692
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:153168
      UIM; Ubiquitin interaction motif
    3. NM_138802.3NP_620157.1  AN1-type zinc finger protein 2B isoform 1

      See identical proteins and their annotated locations for NP_620157.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC068946, BC018415, BM852092
      Consensus CDS
      CCDS2435.1
      UniProtKB/Swiss-Prot
      Q8WV99
      UniProtKB/TrEMBL
      A0A024R435
      Related
      ENSP00000289528.5, ENST00000289528.10
      Conserved Domains (3) summary
      pfam01428
      Location:100136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:197212
      UIM; Ubiquitin interaction motif
      pfam06012
      Location:139244
      DUF908; Domain of Unknown Function (DUF908)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      219206782..219209648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003368.1XP_016858857.1  AN1-type zinc finger protein 2B isoform X2

      UniProtKB/Swiss-Prot
      Q8WV99
      UniProtKB/TrEMBL
      A0A024R435
      Related
      ENSP00000386898.1, ENST00000409336.5
      Conserved Domains (3) summary
      pfam01428
      Location:100136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:197212
      UIM; Ubiquitin interaction motif
      pfam06012
      Location:139244
      DUF908; Domain of Unknown Function (DUF908)
    2. XM_006712286.3XP_006712349.1  AN1-type zinc finger protein 2B isoform X1

      See identical proteins and their annotated locations for XP_006712349.1

      Conserved Domains (2) summary
      pfam01428
      Location:100136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:197212
      UIM; Ubiquitin interaction motif
    3. XM_006712285.1XP_006712348.1  AN1-type zinc finger protein 2B isoform X1

      See identical proteins and their annotated locations for XP_006712348.1

      Conserved Domains (2) summary
      pfam01428
      Location:100136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:197212
      UIM; Ubiquitin interaction motif
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