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    ZNF280A zinc finger protein 280A [ Homo sapiens (human) ]

    Gene ID: 129025, updated on 2-Oct-2018

    Summary

    Official Symbol
    ZNF280Aprovided by HGNC
    Official Full Name
    zinc finger protein 280Aprovided by HGNC
    Primary source
    HGNC:HGNC:18597
    See related
    Ensembl:ENSG00000169548 Vega:OTTHUMG00000030545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SUHW1; ZNF280; ZNF636; 3'OY11.1
    Summary
    This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014]
    Orthologs

    Genomic context

    See ZNF280A in Genome Data Viewer
    Location:
    22q11.22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (22513736..22520281, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22868060..22874613, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda locus Neighboring gene immunoglobulin lambda variable 7-35 (pseudogene) Neighboring gene uncharacterized LOC648691 Neighboring gene zinc finger protein 280B Neighboring gene IGL region enhancer-blocking element 22-2 Neighboring gene immunoglobulin lambda variable 2-34 (pseudogene) Neighboring gene preferentially expressed antigen in melanoma

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 280A
    Names
    suppressor of hairy wing homolog 1
    zinc finger protein 280
    zinc finger protein 636

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_000002.1 

      Range
      492048..498612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080740.4NP_542778.2  zinc finger protein 280A

      See identical proteins and their annotated locations for NP_542778.2

      Status: REVIEWED

      Source sequence(s)
      AC246793, BC053901, BP283207
      Consensus CDS
      CCDS13800.1
      UniProtKB/Swiss-Prot
      P59817
      UniProtKB/TrEMBL
      A0A0G2JN84
      Related
      ENSP00000302855.3, OTTHUMP00000028764, ENST00000302097.3, OTTHUMT00000075433
      Conserved Domains (2) summary
      sd00017
      Location:336357
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:47217
      DUF4195; Domain of unknown function (DUF4195)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

      Range
      22513736..22520281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p12 ALT_REF_LOCI_1

    Genomic

    1. NT_187629.1 Reference GRCh38.p12 ALT_REF_LOCI_1

      Range
      149393..155938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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