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    Clu clusterin [ Mus musculus (house mouse) ]

    Gene ID: 12759, updated on 9-Sep-2018

    Summary

    Official Symbol
    Cluprovided by MGI
    Official Full Name
    clusterinprovided by MGI
    Primary source
    MGI:MGI:88423
    See related
    Ensembl:ENSMUSG00000022037 Vega:OTTMUSG00000032654
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cli; ApoJ; Sgp2; SP-40; Sgp-2; Sugp-2; AI893575; D14Ucla3
    Summary
    The protein encoded by this gene is a secreted chaperone that can, under some stress conditions, also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric mature protein comprised of alpha and beta subunits. Mice lacking the encoded protein exhibit increased severity of autoimmune myocarditis, faster progression of the acute inflammation to myocardial scarring and decreased brain injury following neonatal hypoxic-ischemic injury. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in genital fat pad adult (RPKM 3056.5), ovary adult (RPKM 788.7) and 11 other tissues See more
    Orthologs

    Genomic context

    See Clu in Genome Data Viewer
    Location:
    14 D1; 14 34.36 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (65968483..65981548)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66587320..66600382)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41182 Neighboring gene scavenger receptor class A, member 3 Neighboring gene protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform pseudogene Neighboring gene gulonolactone (L-) oxidase Neighboring gene a disintegrin and metallopeptidase domain 2 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    misfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    central nervous system myelin maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    endocrine pancreas development ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    microglial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular response to thapsigargin ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular response to tunicamycin ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein homooligomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of amyloid-beta formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurofibrillary tangle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein import ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuronal signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    response to misfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neurofibrillary tangle ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    spherical high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    clusterin
    Names
    Apolipoprotein J
    clustrin
    complement lysis inhibitor
    sulfated glycoprotein 2
    testosterone repressed prostate message
    testosterone repressed prostate message-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013492.3NP_038520.2  clusterin preproprotein

      See identical proteins and their annotated locations for NP_038520.2

      Status: REVIEWED

      Source sequence(s)
      BC075668, BP769702, BY248781
      Consensus CDS
      CCDS36957.1
      UniProtKB/Swiss-Prot
      Q06890
      UniProtKB/TrEMBL
      Q549A5
      Related
      ENSMUSP00000022616.6, OTTMUSP00000043417, ENSMUST00000022616.13, OTTMUST00000081231
      Conserved Domains (3) summary
      smart00030
      Location:22226
      CLb; CLUSTERIN Beta chain
      smart00035
      Location:227442
      CLa; CLUSTERIN alpha chain
      pfam01093
      Location:29444
      Clusterin; Clusterin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      65968483..65981548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518504.3XP_006518567.1  clusterin isoform X2

      See identical proteins and their annotated locations for XP_006518567.1

      UniProtKB/Swiss-Prot
      Q06890
      UniProtKB/TrEMBL
      Q549A5
      Conserved Domains (3) summary
      smart00030
      Location:22226
      CLb; CLUSTERIN Beta chain
      smart00035
      Location:227442
      CLa; CLUSTERIN alpha chain
      pfam01093
      Location:29444
      Clusterin; Clusterin
    2. XM_006518503.3XP_006518566.1  clusterin isoform X1

      Conserved Domains (3) summary
      smart00030
      Location:32236
      CLb; CLUSTERIN Beta chain
      smart00035
      Location:237452
      CLa; CLUSTERIN alpha chain
      pfam01093
      Location:39454
      Clusterin; Clusterin
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