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    Ccng2 cyclin G2 [ Mus musculus (house mouse) ]

    Gene ID: 12452, updated on 9-Sep-2018

    Summary

    Official Symbol
    Ccng2provided by MGI
    Official Full Name
    cyclin G2provided by MGI
    Primary source
    MGI:MGI:1095734
    See related
    Ensembl:ENSMUSG00000029385 Vega:OTTMUSG00000026614
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in CNS E14 (RPKM 30.5), whole brain E14.5 (RPKM 26.3) and 27 other tissues See more
    Orthologs

    Genomic context

    See Ccng2 in Genome Data Viewer
    Location:
    5; 5 E2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (93267573..93276231)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (93696599..93705257)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2010109A12 gene Neighboring gene predicted gene, 42116 Neighboring gene K(lysine) acetyltransferase 2B, pseudogene Neighboring gene predicted gene, 18118

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    • p53 signaling, organism-specific biosystem (from WikiPathways)
      p53 signaling, organism-specific biosystemhttp://www.kegg.jp/ (mmu04115) p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcription...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC113793

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007635.4NP_031661.3  cyclin-G2

      See identical proteins and their annotated locations for NP_031661.3

      Status: VALIDATED

      Source sequence(s)
      AK168891, BC088980, BE957050, BY065574
      Consensus CDS
      CCDS19437.1
      UniProtKB/Swiss-Prot
      O08918
      UniProtKB/TrEMBL
      Q3TG40, Q5HZK4
      Related
      ENSMUSP00000031331.6, OTTMUSP00000032879, ENSMUST00000031331.12, OTTMUST00000065855
      Conserved Domains (1) summary
      pfam00134
      Location:74153
      Cyclin_N; Cyclin, N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      93267573..93276231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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