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    Cbx1 chromobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 12412, updated on 12-Aug-2018

    Summary

    Official Symbol
    Cbx1provided by MGI
    Official Full Name
    chromobox 1provided by MGI
    Primary source
    MGI:MGI:105369
    See related
    Ensembl:ENSMUSG00000018666 Vega:OTTMUSG00000001636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cbx; M31; HP1B; MOD1; Cbx-rs2; Hp1beta; E430007M08Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 39.9), CNS E14 (RPKM 17.9) and 27 other tissues See more
    Orthologs

    Genomic context

    See Cbx1 in Genome Data Viewer
    Location:
    11 D; 11 60.11 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (96788679..96808982)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (96650450..96669954)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene src family associated phosphoprotein 1 Neighboring gene predicted gene, 38448 Neighboring gene sorting nexin 11 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene nuclear factor, erythroid derived 2,-like 1 Neighboring gene microRNA 152 Neighboring gene coatomer protein complex, subunit zeta 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone methyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    chromocenter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    female pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    male pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    spindle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    chromobox protein homolog 1
    Names
    chromobox homolog 1
    heterochromatin protein 1 homolog beta
    heterochromatin protein p25
    modifier 1 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362560.1NP_001349489.1  chromobox protein homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596384
      Conserved Domains (2) summary
      pfam00385
      Location:2770
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam01393
      Location:118170
      Chromo_shadow; Chromo shadow domain
    2. NM_001362561.1NP_001349490.1  chromobox protein homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596384
      Conserved Domains (2) summary
      pfam00385
      Location:2770
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam01393
      Location:118170
      Chromo_shadow; Chromo shadow domain
    3. NM_001362563.1NP_001349492.1  chromobox protein homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596384
      Conserved Domains (2) summary
      pfam00385
      Location:2770
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam01393
      Location:118170
      Chromo_shadow; Chromo shadow domain
    4. NM_001362564.1NP_001349493.1  chromobox protein homolog 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK017608, AL596384
    5. NM_007622.4NP_031648.1  chromobox protein homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_031648.1

      Status: VALIDATED

      Source sequence(s)
      AK014215, AL596384
      Consensus CDS
      CCDS25303.1
      UniProtKB/Swiss-Prot
      P83917
      Related
      ENSMUSP00000091475.3, OTTMUSP00000001556, ENSMUST00000093943.9
      Conserved Domains (2) summary
      pfam00385
      Location:2770
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam01393
      Location:118170
      Chromo_shadow; Chromo shadow domain

    RNA

    1. NR_155761.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL596384, BC055290

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      96788679..96808982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314242.1XP_017169731.1  chromobox protein homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      P83917
      Conserved Domains (2) summary
      pfam00385
      Location:2770
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam01393
      Location:118170
      Chromo_shadow; Chromo shadow domain
    2. XM_011248704.2XP_011247006.1  chromobox protein homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      P83917
      Conserved Domains (2) summary
      pfam00385
      Location:2770
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam01393
      Location:118170
      Chromo_shadow; Chromo shadow domain
    3. XM_006532100.2XP_006532163.1  chromobox protein homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      P83917
      Conserved Domains (2) summary
      pfam00385
      Location:2770
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam01393
      Location:118170
      Chromo_shadow; Chromo shadow domain
    4. XM_006532102.2XP_006532165.1  chromobox protein homolog 1 isoform X2

      Related
      ENSMUSP00000137834.1, OTTMUSP00000063049, ENSMUST00000134585.7, OTTMUST00000003221
      Conserved Domains (2) summary
      pfam00385
      Location:2770
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      cl00044
      Location:111137
      ChSh; Chromo Shadow Domain, found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain; Chromo domains mediate the interaction of the heterochromatin with other heterochromatin proteins, thereby affecting chromatin structure (e.g. ...
    5. XM_006532099.2XP_006532162.1  chromobox protein homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      P83917
      Conserved Domains (2) summary
      pfam00385
      Location:2770
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      pfam01393
      Location:118170
      Chromo_shadow; Chromo shadow domain

    RNA

    1. XR_388342.2 RNA Sequence

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