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    TPPP2 tubulin polymerization promoting protein family member 2 [ Homo sapiens (human) ]

    Gene ID: 122664, updated on 9-Sep-2018

    Summary

    Official Symbol
    TPPP2provided by HGNC
    Official Full Name
    tubulin polymerization promoting protein family member 2provided by HGNC
    Primary source
    HGNC:HGNC:19293
    See related
    Ensembl:ENSG00000179636 MIM:616956; Vega:OTTHUMG00000171071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P18; CT152; C14orf8; p25beta
    Expression
    Biased expression in testis (RPKM 37.8) and salivary gland (RPKM 2.8) See more
    Orthologs

    Genomic context

    See TPPP2 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (21024262..21036352)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21498345..21500334)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 2 Neighboring gene NDRG family member 2 Neighboring gene microRNA 6717 Neighboring gene ribonuclease A family member 13 (inactive) Neighboring gene uncharacterized LOC105370398 Neighboring gene ribonuclease A family member 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    General gene information

    Markers

    Homology

    Clone Names

    • AL161668.5

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT microtubule bundle formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    tubulin polymerization-promoting protein family member 2
    Names
    TPPP/p18
    protein p25-beta

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173846.4NP_776245.2  tubulin polymerization-promoting protein family member 2

      See identical proteins and their annotated locations for NP_776245.2

      Status: VALIDATED

      Source sequence(s)
      AW135537, BC038970, DB458250
      Consensus CDS
      CCDS9566.1
      UniProtKB/Swiss-Prot
      P59282
      Related
      ENSP00000317595.6, OTTHUMP00000028309, ENST00000321760.10, OTTHUMT00000073914
      Conserved Domains (1) summary
      pfam05517
      Location:6161
      p25-alpha; p25-alpha

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      21024262..21036352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020966.1XP_016876455.1  tubulin polymerization-promoting protein family member 2 isoform X1

      UniProtKB/Swiss-Prot
      P59282
      Conserved Domains (1) summary
      pfam05517
      Location:6161
      p25-alpha; p25-alpha
    2. XM_005267324.4XP_005267381.1  tubulin polymerization-promoting protein family member 2 isoform X1

      See identical proteins and their annotated locations for XP_005267381.1

      UniProtKB/Swiss-Prot
      P59282
      Related
      ENSP00000435356.2, OTTHUMP00000245037, ENST00000530140.6, OTTHUMT00000411537
      Conserved Domains (1) summary
      pfam05517
      Location:6161
      p25-alpha; p25-alpha
    3. XM_011536416.1XP_011534718.1  tubulin polymerization-promoting protein family member 2 isoform X2

      Related
      ENSP00000423171.1, OTTHUMP00000218007, ENST00000472458.5, OTTHUMT00000073916
      Conserved Domains (1) summary
      pfam05517
      Location:8109
      p25-alpha; p25-alpha
    4. XM_011536420.2XP_011534722.1  tubulin polymerization-promoting protein family member 2 isoform X3

      See identical proteins and their annotated locations for XP_011534722.1

      Conserved Domains (1) summary
      pfam05517
      Location:8109
      p25-alpha; p25-alpha
    5. XM_011536418.1XP_011534720.1  tubulin polymerization-promoting protein family member 2 isoform X3

      See identical proteins and their annotated locations for XP_011534720.1

      Related
      ENSP00000421438.1, OTTHUMP00000218008, ENST00000481535.5, OTTHUMT00000073917
      Conserved Domains (1) summary
      pfam05517
      Location:8109
      p25-alpha; p25-alpha
    6. XM_011536417.2XP_011534719.1  tubulin polymerization-promoting protein family member 2 isoform X3

      See identical proteins and their annotated locations for XP_011534719.1

      Conserved Domains (1) summary
      pfam05517
      Location:8109
      p25-alpha; p25-alpha
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