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    Aup1 ancient ubiquitous protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 11993, updated on 12-Aug-2019

    Summary

    Official Symbol
    Aup1provided by MGI
    Official Full Name
    ancient ubiquitous protein 1provided by MGI
    Primary source
    MGI:MGI:107789
    See related
    Ensembl:ENSMUSG00000068328
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA589454
    Summary
    The protein encoded by this gene contains several conserved domains including a hydrophobic domain, an acetyltransferase domain, a ubiquitin binding domain, and a domain required for recruitment of ubiquitin-conjugating enzyme E2 G2 (Ube2g2). In humans, this protein localizes to the endoplasmic reticulum and to lipid droplets. This protein is thought to be involved both in the degradation of misfolded proteins from the endoplasmic reticulum and in the storage of neutral lipids. Reduced expression of the human ortholog of this gene strongly reduces lipid droplet clustering in the cell, and causes stabilization of misfolded proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 174.0), duodenum adult (RPKM 139.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Aup1 in Genome Data Viewer
    Location:
    6 C3; 6 35.94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83054495..83057682)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (83004647..83007676)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene docking protein 1 Neighboring gene lysyl oxidase-like 3 Neighboring gene microRNA 7040 Neighboring gene HtrA serine peptidase 2 Neighboring gene DEAQ RNA-dependent ATPase Neighboring gene T cell leukemia, homeobox 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Hrd1p ubiquitin ligase ERAD-L complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ancient ubiquitous protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301649.1NP_001288578.1  ancient ubiquitous protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001288578.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK158035, BM900175, BY234324
      UniProtKB/TrEMBL
      I6L970, Q3TBX5
      Conserved Domains (2) summary
      cd14420
      Location:167211
      CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins
      cl17185
      Location:33135
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
    2. NM_007517.4NP_031543.2  ancient ubiquitous protein 1 isoform 1

      See identical proteins and their annotated locations for NP_031543.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK158035, BM900175, BY234324
      Consensus CDS
      CCDS39526.1
      UniProtKB/TrEMBL
      Q3TBX5, Q3U3K9
      Related
      ENSMUSP00000090281.6, ENSMUST00000092618.8
      Conserved Domains (2) summary
      cd14420
      Location:325369
      CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins
      cl17185
      Location:95293
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    RNA

    1. NR_125891.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK158035, AK167335, BM900175, BY234324
      Related
      ENSMUST00000203915.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

      Range
      83054495..83057682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_377416.3 RNA Sequence

    2. XR_377415.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025446.1: Suppressed sequence

      Description
      NM_001025446.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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