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    Kcnj4 potassium voltage-gated channel subfamily J member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116649, updated on 12-Aug-2018

    Summary

    Official Symbol
    Kcnj4provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily J member 4provided by RGD
    Primary source
    RGD:621436
    See related
    Ensembl:ENSRNOG00000013869 Vega:OTTRNOG00000000735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hirk2
    Summary
    inwardly-rectifying potassium channel [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 73.5) and Lung (RPKM 12.5) See more
    Orthologs

    Genomic context

    See Kcnj4 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120717378..120744602, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (120710647..120738030, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 184B Neighboring gene casein kinase 1, epsilon Neighboring gene KDEL endoplasmic reticulum protein retention receptor 3 Neighboring gene DEAD-box helicase 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    potassium ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inward rectifier potassium channel 4
    Names
    BIR11
    IRK-3
    IRK3
    brain inwardly rectifying K(+) channel 2
    inward rectifier K(+) channel Kir2.3
    potassium channel, inwardly rectifying subfamily J member 4
    potassium inwardly-rectifying channel, subfamily J, member 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053870.2NP_446322.2  inward rectifier potassium channel 4

      See identical proteins and their annotated locations for NP_446322.2

      Status: VALIDATED

      Source sequence(s)
      AABR03059195, X87635
      UniProtKB/Swiss-Prot
      P52190
      UniProtKB/TrEMBL
      G3V9M7
      Related
      ENSRNOP00000053014.1, OTTRNOP00000000544, ENSRNOT00000018564.6, OTTRNOT00000001074
      Conserved Domains (1) summary
      pfam01007
      Location:22357
      IRK; Inward rectifier potassium channel

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      120717378..120744602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241963.3XP_006242025.1  inward rectifier potassium channel 4 isoform X1

      See identical proteins and their annotated locations for XP_006242025.1

      UniProtKB/TrEMBL
      G3V9M7
      Conserved Domains (1) summary
      pfam01007
      Location:22357
      IRK; Inward rectifier potassium channel
    2. XM_017594575.1XP_017450064.1  inward rectifier potassium channel 4 isoform X1

      UniProtKB/TrEMBL
      G3V9M7
    3. XM_006241964.3XP_006242026.1  inward rectifier potassium channel 4 isoform X1

      See identical proteins and their annotated locations for XP_006242026.1

      UniProtKB/TrEMBL
      G3V9M7
      Conserved Domains (1) summary
      pfam01007
      Location:22357
      IRK; Inward rectifier potassium channel

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      107378714..107405561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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