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    S100a8 S100 calcium binding protein A8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116547, updated on 13-Aug-2019

    Summary

    Official Symbol
    S100a8provided by RGD
    Official Full Name
    S100 calcium binding protein A8provided by RGD
    Primary source
    RGD:620265
    See related
    Ensembl:ENSRNOG00000011557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrp8
    Summary
    may play a role in inflammatory response [RGD, Feb 2006]
    Expression
    Biased expression in Spleen (RPKM 940.1), Thymus (RPKM 256.3) and 1 other tissue See more
    Orthologs

    Genomic context

    See S100a8 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (190073239..190074333)
    106 current Rn_Celera (GCF_000002265.2) 2 AC_000070.1 (170099876..170100395)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (209507598..209508692)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A6 Neighboring gene S100 calcium binding protein A7A Neighboring gene S100 calcium binding protein A9 Neighboring gene similar to nudix-type motif 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    RAGE receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Toll-like receptor 4 binding IEA
    Inferred from Electronic Annotation
    more info
     
    antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
     
    arachidonic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acute inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    astrocyte development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    autocrine signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    autophagy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    chronic inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte migration involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    leukocyte migration involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil aggregation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neutrophil aggregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-cysteine S-nitrosylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-cysteine S-nitrosylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of peptide secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein S100-A8
    Names
    MRP-8
    S100 calcium binding protein A8 (calgranulin A)
    calgranulin-A
    migration inhibitory factor-related protein 8
    p8

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053822.2NP_446274.2  protein S100-A8

      See identical proteins and their annotated locations for NP_446274.2

      Status: VALIDATED

      Source sequence(s)
      AC097705
      UniProtKB/Swiss-Prot
      P50115
      Related
      ENSRNOP00000015473.1, ENSRNOT00000015473.3
      Conserved Domains (1) summary
      cd05030
      Location:386
      calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      190073239..190074333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232565.3XP_006232627.1  protein S100-A8 isoform X1

      See identical proteins and their annotated locations for XP_006232627.1

      UniProtKB/Swiss-Prot
      P50115
      Conserved Domains (1) summary
      cd05030
      Location:386
      calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      170099876..170100395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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