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    Parp2 poly (ADP-ribose) polymerase family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 11546, updated on 11-Jun-2019

    Summary

    Official Symbol
    Parp2provided by MGI
    Official Full Name
    poly (ADP-ribose) polymerase family, member 2provided by MGI
    Primary source
    MGI:MGI:1341112
    See related
    Ensembl:ENSMUSG00000036023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARTD2; Adprt2; C78626; PARP-2; ADPRT-2; Adprtl2; mPARP-2; Aspartl2; pADPRT-2
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 20.7), liver E14 (RPKM 15.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See Parp2 in Genome Data Viewer
    Location:
    14 26.25 cM; 14 C1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (50807897..50821301)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (51427621..51440975)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene cyclin B1 interacting protein 1 Neighboring gene ribonuclease P RNA component H1 Neighboring gene telomerase associated protein 1 Neighboring gene predicted gene, 26782 Neighboring gene kelch-like 33

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • BER complex, organism-specific biosystem (from KEGG)
      BER complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • BER complex, conserved biosystem (from KEGG)
      BER complex, conserved biosystemStructural complex; Genetic information processing; Repair system
    • Base excision repair, organism-specific biosystem (from KEGG)
      Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Base excision repair, conserved biosystem (from KEGG)
      Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ADP-ribosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ADP-ribosylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    protein poly-ADP-ribosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein poly-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    poly [ADP-ribose] polymerase 2
    Names
    ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2
    ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 2
    ADP-ribosyltransferase diphtheria toxin-like 2
    DNA ADP-ribosyltransferase PARP2
    NAD(+) ADP-ribosyltransferase 2
    poly[ADP-ribose] synthase 2
    poly[ADP-ribose] synthetase 2
    protein poly-ADP-ribosyltransferase PARP2
    NP_033762.1
    XP_006518505.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009632.3NP_033762.1  poly [ADP-ribose] polymerase 2

      See identical proteins and their annotated locations for NP_033762.1

      Status: VALIDATED

      Source sequence(s)
      AC027184
      Consensus CDS
      CCDS27025.1
      UniProtKB/Swiss-Prot
      O88554
      Related
      ENSMUSP00000048877.5, ENSMUST00000036126.6
      Conserved Domains (3) summary
      cd08003
      Location:86188
      WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
      cd01437
      Location:207552
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:341553
      PARP; Poly(ADP-ribose) polymerase catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      50807897..50821301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518442.3XP_006518505.1  poly [ADP-ribose] polymerase 2 isoform X1

      See identical proteins and their annotated locations for XP_006518505.1

      UniProtKB/Swiss-Prot
      O88554
      Conserved Domains (3) summary
      cd08003
      Location:49151
      WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
      cd01437
      Location:170515
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:304516
      PARP; Poly(ADP-ribose) polymerase catalytic domain
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