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    FBXO17 F-box protein 17 [ Homo sapiens (human) ]

    Gene ID: 115290, updated on 8-Jul-2021

    Summary

    Official Symbol
    FBXO17provided by HGNC
    Official Full Name
    F-box protein 17provided by HGNC
    Primary source
    HGNC:HGNC:18754
    See related
    Ensembl:ENSG00000269190 MIM:609094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBG4; FBX26; Fbx17; FBXO26
    Summary
    This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Broad expression in kidney (RPKM 11.1), ovary (RPKM 9.9) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FBXO17 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38941401..38975742, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39432041..39466382, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene seryl-tRNA synthetase 2, mitochondrial Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene F-box protein 27 Neighboring gene acid phosphatase 7, tartrate resistant (putative)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Potential readthrough

    Included gene: SARS2

    Homology

    Clone Names

    • MGC9379, FLJ11798, FLJ25205, FLJ58300

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    F-box only protein 17
    Names
    F-box only protein 26
    F-box protein FBG4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050566.1 RefSeqGene

      Range
      5072..39413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_024907.7NP_079183.4  F-box only protein 17 isoform 2

      See identical proteins and their annotated locations for NP_079183.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the shorter isoform (2).
      Source sequence(s)
      AF386743, AI050825, BM711851, CA429117, CF594009
      Consensus CDS
      CCDS12526.1
      UniProtKB/Swiss-Prot
      Q96EF6
      Related
      ENSP00000292852.3, ENST00000292852.9
      Conserved Domains (2) summary
      pfam04300
      Location:100271
      FBA; F-box associated region
      pfam12937
      Location:1859
      F-box-like
    2. NM_148169.3NP_680474.1  F-box only protein 17 isoform 1

      See identical proteins and their annotated locations for NP_680474.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 2. It encodes isoform 1, which has a longer N-terminus, compared to isoform 2.
      Source sequence(s)
      AF386743, AI050825, AK057934, BM711851, CA429117
      UniProtKB/Swiss-Prot
      Q96EF6
      Conserved Domains (2) summary
      pfam04300
      Location:110282
      FBA; F-box associated region
      pfam12937
      Location:2768
      F-box-like; F-box-like

    RNA

    1. NR_104026.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and uses an alternate splice site in an internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF386743, AI050825, BM711851, BX338290, CA429117, CF594009

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      38941401..38975742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_014040929.1 Reference GRCh38.p13 PATCHES

      Range
      351073..385414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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