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    Abl1 c-abl oncogene 1, non-receptor tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 11350, updated on 9-Oct-2018

    Summary

    Official Symbol
    Abl1provided by MGI
    Official Full Name
    c-abl oncogene 1, non-receptor tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:87859
    See related
    Ensembl:ENSMUSG00000026842 Vega:OTTMUSG00000012077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abl; c-Abl; AI325092; E430008G22Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 24.4), limb E14.5 (RPKM 24.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Abl1 in Genome Data Viewer
    Location:
    2 21.86 cM; 2 B
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (31688354..31807093)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (31544076..31659747)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene PR domain containing 12 Neighboring gene exosome component 2 Neighboring gene predicted gene 13427 Neighboring gene fibrinogen C domain containing 1 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene laminin gamma 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117749

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    delta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    manganese ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    neuropilin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    neuropilin binding ISO
    Inferred from Sequence Orthology
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    B cell proliferation involved in immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    B cell proliferation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    B-1 B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Bergmann glial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    DNA damage induced protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    actin filament branching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    alpha-beta T cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cardiovascular system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    microspike assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cellular senescence IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of endothelial cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuroepithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuropilin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation blood vessel branching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-gamma secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of interleukin-2 secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of sequestered calcium ion into cytosol IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Cdc42 protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cellular senescence IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of modification of synaptic structure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transitional one stage B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase ABL1
    Names
    Abelson murine leukemia oncogene
    Abelson tyrosine-protein kinase 1
    abelson murine leukemia viral oncogene homolog 1
    c-abl oncogene 1, receptor tyrosine kinase
    c-abl protein, type I
    c-abl protein, type II
    c-abl protein, type III
    p150
    proto-oncogene c-Abl
    proto-oncogene tyrosine-protein kinase ABL1
    v-abl Abelson murine leukemia oncogene 1
    NP_001106174.1
    NP_001269974.1
    NP_001269975.1
    NP_001269976.1
    NP_033724.2
    XP_006497684.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112703.2NP_001106174.1  tyrosine-protein kinase ABL1 isoform a

      See identical proteins and their annotated locations for NP_001106174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform a).
      Source sequence(s)
      AK166028, AL929275, BC103770
      Consensus CDS
      CCDS50563.1
      UniProtKB/Swiss-Prot
      P00520
      UniProtKB/TrEMBL
      Q3SYK5
      Related
      ENSMUSP00000075167.6, OTTMUSP00000013004, ENSMUST00000075759.12, OTTMUST00000028740
      Conserved Domains (5) summary
      smart00808
      Location:10181142
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:142235
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:84137
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:254516
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:261512
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_001283045.1NP_001269974.1  tyrosine-protein kinase ABL1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform c) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL929275, BQ769074, CF536749, CF726668, CF727094
      UniProtKB/Swiss-Prot
      P00520
      Conserved Domains (5) summary
      smart00808
      Location:9941118
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:118211
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:60113
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:230492
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:237488
      Pkinase_Tyr; Protein tyrosine kinase
    3. NM_001283046.1NP_001269975.1  tyrosine-protein kinase ABL1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' exon compared to variant 1, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform d) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL929275
      UniProtKB/Swiss-Prot
      P00520
      Conserved Domains (5) summary
      smart00808
      Location:9931117
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:117210
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:59112
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:229491
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:236487
      Pkinase_Tyr; Protein tyrosine kinase
    4. NM_001283047.1NP_001269976.1  tyrosine-protein kinase ABL1 isoform e

      See identical proteins and their annotated locations for NP_001269976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' exon and uses a downstream start codon compared to variant 1. The resulting protein (isoform e) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL929275
      Conserved Domains (3) summary
      smart00808
      Location:763887
      FABD; F-actin binding domain (FABD)
      cd05052
      Location:1261
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:6257
      Pkinase_Tyr; Protein tyrosine kinase
    5. NM_009594.4NP_033724.2  tyrosine-protein kinase ABL1 isoform b

      See identical proteins and their annotated locations for NP_033724.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL929275, BM949741, BU053120, CA752052, CF726668, CF727248, CJ099623, CJ101520, CJ128107, CK626997, CN663033
      Consensus CDS
      CCDS15901.1
      UniProtKB/Swiss-Prot
      P00520
      Related
      ENSMUSP00000028190.6, OTTMUSP00000013005, ENSMUST00000028190.12, OTTMUST00000028747
      Conserved Domains (5) summary
      smart00808
      Location:9991123
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:123216
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:65118
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:235497
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:242493
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      31688354..31807093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497621.3XP_006497684.1  tyrosine-protein kinase ABL1 isoform X1

      Conserved Domains (4) summary
      cd09935
      Location:142235
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:84137
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:254516
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:261512
      Pkinase_Tyr; Protein tyrosine kinase
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