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    LZTS1 leucine zipper tumor suppressor 1 [ Homo sapiens (human) ]

    Gene ID: 11178, updated on 15-Sep-2018

    Summary

    Official Symbol
    LZTS1provided by HGNC
    Official Full Name
    leucine zipper tumor suppressor 1provided by HGNC
    Primary source
    HGNC:HGNC:13861
    See related
    Ensembl:ENSG00000061337 MIM:606551; Vega:OTTHUMG00000097027
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    F37; FEZ1
    Summary
    This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
    Expression
    Broad expression in testis (RPKM 4.1), brain (RPKM 3.1) and 19 other tissues See more
    Orthologs

    Genomic context

    See LZTS1 in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (20246165..20303981, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (20103676..20161492, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit B2 Neighboring gene RNA, U6 small nuclear 892, pseudogene Neighboring gene LZTS1 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 257 Neighboring gene uncharacterized LOC105379314 Neighboring gene uncharacterized LOC107986881

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Malignant tumor of esophagus
    MedGen: C0546837 OMIM: 133239 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
    NHGRI GWA Catalog
    Genome-wide association scan of dental caries in the permanent dentition.
    NHGRI GWA Catalog
    Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
    NHGRI GWA Catalog
    GWAS of dental caries patterns in the permanent dentition.
    NHGRI GWA Catalog
    Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leucine zipper putative tumor suppressor 1
    Names
    F37/Esophageal cancer-related gene-coding leucine-zipper motif
    leucine zipper, putative tumor suppressor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015834.3 RefSeqGene

      Range
      5001..62817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001362884.1NP_001349813.1  leucine zipper putative tumor suppressor 1

      Status: REVIEWED

      Source sequence(s)
      AC025853, AF123659, BX344344, HY107963
      Consensus CDS
      CCDS6015.1
      Conserved Domains (2) summary
      pfam06818
      Location:380564
      Fez1; Fez1
      cl25732
      Location:235513
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_021020.4NP_066300.1  leucine zipper putative tumor suppressor 1

      See identical proteins and their annotated locations for NP_066300.1

      Status: REVIEWED

      Source sequence(s)
      AC025853, AF123659, BX344344, HY107963
      Consensus CDS
      CCDS6015.1
      UniProtKB/Swiss-Prot
      Q9Y250
      Related
      ENSP00000265801.6, ENST00000265801.6
      Conserved Domains (2) summary
      pfam06818
      Location:380564
      Fez1; Fez1
      cl25732
      Location:235513
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

      Range
      20246165..20303981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273394.3XP_005273451.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y250
      Related
      ENSP00000370981.1, OTTHUMP00000122524, ENST00000381569.5, OTTHUMT00000214122
      Conserved Domains (2) summary
      pfam06818
      Location:380564
      Fez1; Fez1
      cl25732
      Location:235513
      SMC_N; RecF/RecN/SMC N terminal domain
    2. XM_011544383.2XP_011542685.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y250
      Conserved Domains (2) summary
      pfam06818
      Location:380564
      Fez1; Fez1
      cl25732
      Location:235513
      SMC_N; RecF/RecN/SMC N terminal domain
    3. XM_011544385.2XP_011542687.1  leucine zipper putative tumor suppressor 1 isoform X1

      See identical proteins and their annotated locations for XP_011542687.1

      UniProtKB/Swiss-Prot
      Q9Y250
      Conserved Domains (2) summary
      pfam06818
      Location:380564
      Fez1; Fez1
      cl25732
      Location:235513
      SMC_N; RecF/RecN/SMC N terminal domain
    4. XM_011544386.2XP_011542688.1  leucine zipper putative tumor suppressor 1 isoform X1

      See identical proteins and their annotated locations for XP_011542688.1

      UniProtKB/Swiss-Prot
      Q9Y250
      Conserved Domains (2) summary
      pfam06818
      Location:380564
      Fez1; Fez1
      cl25732
      Location:235513
      SMC_N; RecF/RecN/SMC N terminal domain
    5. XM_011544384.2XP_011542686.1  leucine zipper putative tumor suppressor 1 isoform X1

      See identical proteins and their annotated locations for XP_011542686.1

      UniProtKB/Swiss-Prot
      Q9Y250
      Conserved Domains (2) summary
      pfam06818
      Location:380564
      Fez1; Fez1
      cl25732
      Location:235513
      SMC_N; RecF/RecN/SMC N terminal domain
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