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    FOXN3 forkhead box N3 [ Homo sapiens (human) ]

    Gene ID: 1112, updated on 8-Jul-2018
    Official Symbol
    FOXN3provided by HGNC
    Official Full Name
    forkhead box N3provided by HGNC
    Primary source
    HGNC:HGNC:1928
    See related
    Ensembl:ENSG00000053254 MIM:602628; Vega:OTTHUMG00000170898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHES1; PRO1635; C14orf116
    Summary
    This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 25.7), ovary (RPKM 24.3) and 25 other tissues See more
    Orthologs
    See FOXN3 in Genome Data Viewer
    Location:
    14q31.3-q32.11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (89156172..89619150, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (89622516..90085506, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370615 Neighboring gene metallophosphoesterase 1 pseudogene 1 Neighboring gene cyclase associated actin cytoskeleton regulatory protein 2 pseudogene 1 Neighboring gene uncharacterized LOC101928817 Neighboring gene uncharacterized LOC107984635 Neighboring gene FOXN3 antisense RNA 1 Neighboring gene FOXN3 antisense RNA 2 Neighboring gene uncharacterized LOC105370617 Neighboring gene uncharacterized LOC105370616 Neighboring gene RNA, 7SK small nuclear pseudogene 107

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    NHGRI GWA Catalog
    Weight loss after gastric bypass is associated with a variant at 15q26.1.
    NHGRI GWA Catalog
    • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    craniofacial suture morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic G2 DNA damage checkpoint IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    Preferred Names
    forkhead box protein N3
    Names
    checkpoint suppressor 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085471.1NP_001078940.1  forkhead box protein N3 isoform 1

      See identical proteins and their annotated locations for NP_001078940.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI084011, AL138478, BP213901, U68723
      Consensus CDS
      CCDS41977.1
      UniProtKB/Swiss-Prot
      O00409
      UniProtKB/TrEMBL
      A0A024R6I1
      Related
      ENSP00000343288.4, OTTHUMP00000244668, ENST00000345097.8, OTTHUMT00000410902
      Conserved Domains (1) summary
      pfam00250
      Location:114201
      Forkhead; Forkhead domain
    2. NM_005197.3NP_005188.2  forkhead box protein N3 isoform 2

      See identical proteins and their annotated locations for NP_005188.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and differs in the 5' UTR, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AI084011, AL138478, BC007506, CB989352
      Consensus CDS
      CCDS32138.1
      UniProtKB/Swiss-Prot
      O00409
      Related
      ENSP00000452005.1, OTTHUMP00000244669, ENST00000557258.5, OTTHUMT00000410903
      Conserved Domains (1) summary
      pfam00250
      Location:114200
      Forkhead; Forkhead domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      89156172..89619150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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