Format

Send to:

Choose Destination
    • Showing Current items.

    ADAM29 ADAM metallopeptidase domain 29 [ Homo sapiens (human) ]

    Gene ID: 11086, updated on 29-Mar-2018

    Summary

    Official Symbol
    ADAM29provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 29provided by HGNC
    Primary source
    HGNC:HGNC:207
    See related
    Ensembl:ENSG00000168594 MIM:604778; Vega:OTTHUMG00000160764
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT73; svph1
    Summary
    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 20.8) See more
    Orthologs

    Genomic context

    See ADAM29 in Genome Data Viewer
    Location:
    4q34.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (174918358..174978180)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (175839509..175899331)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene glycine receptor alpha 3 Neighboring gene uncharacterized LOC101928551 Neighboring gene uncharacterized LOC105377552 Neighboring gene disintegrin and metalloproteinase domain-containing protein 21-like Neighboring gene PC4 and SFRS1 interacting protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 29
    Names
    a disintegrin and metalloproteinase domain 29
    cancer/testis antigen 73
    metallaproteinase-disintegrin (ADAM29)
    testis secretory sperm-binding protein Li 207a

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130703.1NP_001124175.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

      See identical proteins and their annotated locations for NP_001124175.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
      Source sequence(s)
      AK292410, BC036070, DB051105, DB073142
      Consensus CDS
      CCDS3823.1
      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Related
      ENSP00000414544.1, ENST00000445694.5
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein
    2. NM_001130704.1NP_001124176.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

      See identical proteins and their annotated locations for NP_001124176.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
      Source sequence(s)
      AK292410, BC036070, DB073142, DB080702
      Consensus CDS
      CCDS3823.1
      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Related
      ENSP00000384229.3, OTTHUMP00000218945, ENST00000404450.8, OTTHUMT00000362186
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein
    3. NM_001130705.1NP_001124177.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

      See identical proteins and their annotated locations for NP_001124177.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
      Source sequence(s)
      AK292410, BC036070, DB039551, DB073142
      Consensus CDS
      CCDS3823.1
      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Related
      ENSP00000423517.1, OTTHUMP00000218946, ENST00000514159.1, OTTHUMT00000362187
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein
    4. NM_001278125.1NP_001265054.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

      See identical proteins and their annotated locations for NP_001265054.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
      Source sequence(s)
      AC105914, AK292410, BC036070, DB078627
      Consensus CDS
      CCDS3823.1
      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Related
      ENSP00000484862.1, ENST00000615367.4
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein
    5. NM_001278126.1NP_001265055.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

      See identical proteins and their annotated locations for NP_001265055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
      Source sequence(s)
      AK292410, BC036070, DB051105, DB073142, DB078125
      Consensus CDS
      CCDS3823.1
      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein
    6. NM_001278127.1NP_001265056.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

      See identical proteins and their annotated locations for NP_001265056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
      Source sequence(s)
      AK292410, BC036070, DB044176, DB073142
      Consensus CDS
      CCDS3823.1
      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Related
      ENSP00000478469.1, ENST00000618444.1
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein
    7. NM_014269.4NP_055084.3  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

      See identical proteins and their annotated locations for NP_055084.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
      Source sequence(s)
      AK292410, BC036070, DB073142, DB078034, DB080702
      Consensus CDS
      CCDS3823.1
      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Related
      ENSP00000352177.3, ENST00000359240.7
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

      Range
      174918358..174978180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531557.1XP_011529859.1  disintegrin and metalloproteinase domain-containing protein 29 isoform X1

      See identical proteins and their annotated locations for XP_011529859.1

      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein
    2. XM_011531556.1XP_011529858.1  disintegrin and metalloproteinase domain-containing protein 29 isoform X1

      See identical proteins and their annotated locations for XP_011529858.1

      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein
    3. XM_011531559.1XP_011529861.1  disintegrin and metalloproteinase domain-containing protein 29 isoform X1

      See identical proteins and their annotated locations for XP_011529861.1

      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein
    4. XM_011531560.1XP_011529862.1  disintegrin and metalloproteinase domain-containing protein 29 isoform X1

      See identical proteins and their annotated locations for XP_011529862.1

      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein
    5. XM_011531561.1XP_011529863.1  disintegrin and metalloproteinase domain-containing protein 29 isoform X1

      See identical proteins and their annotated locations for XP_011529863.1

      UniProtKB/Swiss-Prot
      Q9UKF5
      UniProtKB/TrEMBL
      A0A140VJD8
      Conserved Domains (7) summary
      smart00608
      Location:483618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:198386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:406479
      Disintegrin; Disintegrin
      pfam01421
      Location:198386
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42149
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08226
      Location:728791
      DUF1720; Domain of unknown function (DUF1720)
      pfam14179
      Location:756814
      YppG; YppG-like protein
    Support Center