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    Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 [ Mus musculus (house mouse) ]

    Gene ID: 110834, updated on 9-Sep-2018

    Summary

    Official Symbol
    Chrna3provided by MGI
    Official Full Name
    cholinergic receptor, nicotinic, alpha polypeptide 3provided by MGI
    Primary source
    MGI:MGI:87887
    See related
    Ensembl:ENSMUSG00000032303 Vega:OTTMUSG00000063118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    (a)3; Acra3; Acra-3; A730007P14Rik
    Expression
    Biased expression in adrenal adult (RPKM 6.2), whole brain E14.5 (RPKM 4.2) and 11 other tissues See more
    Orthologs

    Genomic context

    See Chrna3 in Genome Data Viewer
    Location:
    9; 9 B
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (55011343..55026559, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (54859150..54874366, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene cDNA sequence AY074887 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 5 Neighboring gene cholinergic receptor, nicotinic, beta polypeptide 4 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to acetylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acetylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acetylcholine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acetylcholine-gated cation-selective channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acetylcholine-gated cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to extracellular ligand-gated ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of transmembrane receptor protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuromuscular synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of acetylcholine secretion, neurotransmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    response to acetylcholine ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to nicotine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic transmission involved in micturition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic transmission involved in micturition ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic transmission, cholinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acetylcholine-gated channel complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acetylcholine-gated channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cholinergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholinergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dopaminergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IC
    Inferred by Curator
    more info
    PubMed 
    synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    neuronal acetylcholine receptor subunit alpha-3
    Names
    alpha 3
    neuronal nicotinic acetylcholine receptor, alpha 3 subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145129.2NP_660111.2  neuronal acetylcholine receptor subunit alpha-3 precursor

      See identical proteins and their annotated locations for NP_660111.2

      Status: VALIDATED

      Source sequence(s)
      AK041217, AK051730, AK080415
      Consensus CDS
      CCDS23199.1
      UniProtKB/Swiss-Prot
      Q8R4G9
      UniProtKB/TrEMBL
      Q0VBK4
      Related
      ENSMUSP00000034851.4, OTTMUSP00000079505, ENSMUST00000034851.5, OTTMUST00000153654
      Conserved Domains (3) summary
      TIGR00860
      Location:29495
      LIC; Cation transporter family protein
      pfam02931
      Location:34240
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:247494
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      55011343..55026559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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