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    Nop2 NOP2 nucleolar protein [ Mus musculus (house mouse) ]

    Gene ID: 110109, updated on 2-Oct-2018

    Summary

    Official Symbol
    Nop2provided by MGI
    Official Full Name
    NOP2 nucleolar proteinprovided by MGI
    Primary source
    MGI:MGI:107891
    See related
    Ensembl:ENSMUSG00000038279 Vega:OTTMUSG00000056703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nol1; 120kDa; A530002O17
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 17.5), liver E14 (RPKM 16.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nop2 in Genome Data Viewer
    Location:
    6 F2; 6 59.32 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (125131864..125144753)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (125081901..125094771)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene predicted gene, 32616 Neighboring gene microRNA 7045 Neighboring gene chromodomain helicase DNA binding protein 4 Neighboring gene intermediate filament family orphan 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase Neighboring gene non-SMC condensin I complex, subunit D2 Neighboring gene small Cajal body-specific RNA 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    rRNA (cytosine-C5-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    blastocyst formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    ribosomal large subunit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    probable 28S rRNA (cytosine-C(5))-methyltransferase
    Names
    NOP2 nucleolar protein homolog
    nucleolar protein 1, 120 kDa
    nucleolar protein 2 homolog
    proliferating-cell nucleolar antigen p120
    proliferation-associated nucleolar protein p120
    putative ribosomal RNA methyltransferase NOP2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138747.2NP_620086.2  probable 28S rRNA (cytosine-C(5))-methyltransferase

      Status: VALIDATED

      Source sequence(s)
      AI325393, AK079914, BY244994
      Consensus CDS
      CCDS51912.1
      UniProtKB/TrEMBL
      E9QN31
      Related
      ENSMUSP00000047123.8, OTTMUSP00000073404, ENSMUST00000044200.10, OTTMUST00000139943
      Conserved Domains (4) summary
      TIGR00446
      Location:297571
      nop2p; NOL1/NOP2/sun family putative RNA methylase
      pfam01189
      Location:362570
      Nol1_Nop2_Fmu; 16S rRNA methyltransferase RsmF
      pfam08062
      Location:609630
      P120R; P120R (NUC006) repeat
      pfam17125
      Location:284358
      Methyltr_RsmF_N; N-terminal domain of 16S rRNA methyltransferase RsmF

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      125131864..125144753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321323.1XP_017176812.1  probable 28S rRNA (cytosine-C(5))-methyltransferase isoform X1

    2. XM_017321322.1XP_017176811.1  probable 28S rRNA (cytosine-C(5))-methyltransferase isoform X1

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