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    METAP2 methionyl aminopeptidase 2 [ Homo sapiens (human) ]

    Gene ID: 10988, updated on 9-Sep-2018

    Summary

    Official Symbol
    METAP2provided by HGNC
    Official Full Name
    methionyl aminopeptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:16672
    See related
    Ensembl:ENSG00000111142 MIM:601870; Vega:OTTHUMG00000170280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAP2; MNPEP; p67eIF2
    Summary
    The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in testis (RPKM 26.5), lymph node (RPKM 23.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See METAP2 in Genome Data Viewer
    Location:
    12q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (95474046..95515839)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (95867822..95909615)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984545 Neighboring gene RNA, U6 small nuclear 735, pseudogene Neighboring gene ribosomal protein L29 pseudogene 26 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene phosphoglycerate mutase 1 pseudogene 5 Neighboring gene netrin 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystem (from REACTOME)
      Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystemTo terminate the single photon response and restore the system to its basal state, the three activated intermediates in phototransduction, rhodopsin (MII), transducin alpha subunit with GTP bound (GN...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • The phototransduction cascade, organism-specific biosystem (from REACTOME)
      The phototransduction cascade, organism-specific biosystemThe visual pigment (rhodopsin in rods) consists of an 11-cis-retinal (11cRAL) chromophore covalently attached to a GPCR opsin family member via a Schiff base linkage. Upon photon absorption, 11cRAL i...
    • Visual phototransduction, organism-specific biosystem (from REACTOME)
      Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aminopeptidase activity TAS
    Traceable Author Statement
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metalloexopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    N-terminal protein amino acid modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-methionine modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein initiator methionine removal IEA
    Inferred from Electronic Annotation
    more info
     
    protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of rhodopsin mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    methionine aminopeptidase 2
    Names
    eIF-2-associated p67 homolog
    initiation factor 2-associated 67 kDa glycoprotein
    peptidase M 2
    testicular tissue protein Li 17
    NP_001304111.1
    NP_001304112.1
    NP_001317175.1
    NP_006829.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317182.1NP_001304111.1  methionine aminopeptidase 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC018475, AK300836, DW409106
      Consensus CDS
      CCDS81723.1
      UniProtKB/Swiss-Prot
      P50579
      Related
      ENSP00000448169.1, OTTHUMP00000243394, ENST00000546753.5, OTTHUMT00000408297
      Conserved Domains (1) summary
      PTZ00053
      Location:110455
      PTZ00053; methionine aminopeptidase 2; Provisional
    2. NM_001317183.1NP_001304112.1  methionine aminopeptidase 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC018475, AK091730, DW409106
      Consensus CDS
      CCDS81725.1
      UniProtKB/Swiss-Prot
      P50579
      Related
      ENSP00000261220.9, OTTHUMP00000243395, ENST00000261220.13, OTTHUMT00000408299
      Conserved Domains (1) summary
      PTZ00053
      Location:89455
      PTZ00053; methionine aminopeptidase 2; Provisional
    3. NM_001330246.1NP_001317175.1  methionine aminopeptidase 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice junction in the 5' coding region compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is one amino acid shorter compared to isoform 1.
      Source sequence(s)
      AC018475, AK091730, CA450598, DW409106, U13261
      Consensus CDS
      CCDS81724.1
      UniProtKB/Swiss-Prot
      P50579
      UniProtKB/TrEMBL
      F8VQZ7
      Related
      ENSP00000450063.1, ENST00000551840.5
      Conserved Domains (1) summary
      PTZ00053
      Location:106477
      PTZ00053; methionine aminopeptidase 2; Provisional
    4. NM_006838.3NP_006829.1  methionine aminopeptidase 2 isoform 1

      See identical proteins and their annotated locations for NP_006829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC018475, DW409106, U13261
      Consensus CDS
      CCDS9052.1
      UniProtKB/Swiss-Prot
      P50579
      UniProtKB/TrEMBL
      A0A140VJE3
      Related
      ENSP00000325312.5, OTTHUMP00000243393, ENST00000323666.9, OTTHUMT00000408296
      Conserved Domains (1) summary
      PTZ00053
      Location:107478
      PTZ00053; methionine aminopeptidase 2; Provisional

    RNA

    1. NR_133673.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC018475, AK125296

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      95474046..95515839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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