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    COPS8 COP9 signalosome subunit 8 [ Homo sapiens (human) ]

    Gene ID: 10920, updated on 6-Sep-2021

    Summary

    Official Symbol
    COPS8provided by HGNC
    Official Full Name
    COP9 signalosome subunit 8provided by HGNC
    Primary source
    HGNC:HGNC:24335
    See related
    Ensembl:ENSG00000198612 MIM:616011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    COP9; CSN8; SGN8
    Summary
    The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 28.1), testis (RPKM 22.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See COPS8 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (237085889..237100474)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (237994532..238009117)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373950 Neighboring gene uncharacterized LOC93463 Neighboring gene uncharacterized LOC105373952 Neighboring gene uncharacterized LOC105373953

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with COP9 constitutive photomorphogenic homolog subunit 8 (COPS8; CSN8) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC1297, MGC43256

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    COP9 signalosome complex subunit 8
    Names
    COP9 constitutive photomorphogenic homolog subunit 8
    COP9 homolog
    JAB1-containing signalosome subunit 8
    hCOP9
    signalosome subunit 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006710.5NP_006701.1  COP9 signalosome complex subunit 8 isoform 1

      See identical proteins and their annotated locations for NP_006701.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC105760, AL038738, BC003090, BC036499
      Consensus CDS
      CCDS2517.1
      UniProtKB/Swiss-Prot
      Q99627
      UniProtKB/TrEMBL
      A0A024R4D1
      Related
      ENSP00000346340.2, ENST00000354371.7
      Conserved Domains (1) summary
      pfam10075
      Location:31166
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
    2. NM_198189.3NP_937832.1  COP9 signalosome complex subunit 8 isoform 2

      See identical proteins and their annotated locations for NP_937832.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional exon compared to variant 1, resulting in translation initiation from a downstream start codon and an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC105760, AL038738, BC003090, BF979628
      Consensus CDS
      CCDS42835.1
      UniProtKB/Swiss-Prot
      Q99627
      Related
      ENSP00000375865.2, ENST00000392008.6
      Conserved Domains (1) summary
      pfam10075
      Location:1117
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      237085889..237100474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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