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    Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 107934, updated on 18-Sep-2018

    Summary

    Official Symbol
    Celsr3provided by MGI
    Official Full Name
    cadherin, EGF LAG seven-pass G-type receptor 3provided by MGI
    Primary source
    MGI:MGI:1858236
    See related
    Ensembl:ENSMUSG00000023473 Vega:OTTMUSG00000050676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fmi1; Adgrc3; flamingo; mKIAA0812
    Expression
    Biased expression in whole brain E14.5 (RPKM 20.1), CNS E18 (RPKM 16.6) and 6 other tissues See more
    Orthologs

    Genomic context

    See Celsr3 in Genome Data Viewer
    Location:
    9; 9 F2
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (108826045..108852969)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108728651..108755300)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene NCK interacting protein with SH3 domain Neighboring gene predicted gene, 35025 Neighboring gene solute carrier family 26, member 6 Neighboring gene transmembrane protein 89

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • Non-odorant GPCRs, organism-specific biosystem (from WikiPathways)
      Non-odorant GPCRs, organism-specific biosystemListing of non-odorant Mouse GCPRs by coupling.

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dopaminergic neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    planar cell polarity pathway involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    serotonergic neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cadherin EGF LAG seven-pass G-type receptor 3
    Names
    cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359572.1NP_001346501.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC168054
      Conserved Domains (10) summary
      smart00303
      Location:24742527
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:646743
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:21172181
      HormR; Domain present in hormone receptors
      cd00054
      Location:17171748
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20672105
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:15081691
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:19942033
      Laminin_EGF; Laminin EGF domain
      pfam16489
      Location:22002448
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:25372561
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:25342787
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_001359573.1NP_001346502.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC168054
      Conserved Domains (10) summary
      smart00303
      Location:24742527
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:646743
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:21172181
      HormR; Domain present in hormone receptors
      cd00054
      Location:17171748
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20672105
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:15081691
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:19942033
      Laminin_EGF; Laminin EGF domain
      pfam16489
      Location:22002448
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:25372561
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:25342786
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      108826045..108852969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511621.1XP_006511684.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X1

      UniProtKB/TrEMBL
      A0A1L1SUG9
      Related
      ENSMUSP00000150759.1, OTTMUSP00000079981, ENSMUST00000213524.1, OTTMUST00000154781
      Conserved Domains (10) summary
      smart00303
      Location:24742527
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:646743
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:21172181
      HormR; Domain present in hormone receptors
      cd00054
      Location:17171748
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20672105
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:15081691
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:19942033
      Laminin_EGF; Laminin EGF domain
      pfam16489
      Location:22002448
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:25372561
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:25342787
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_017313096.1XP_017168585.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X2

      Conserved Domains (10) summary
      smart00303
      Location:24742527
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:646743
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:21172181
      HormR; Domain present in hormone receptors
      cd00054
      Location:17171748
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20672105
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:15081691
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:19942033
      Laminin_EGF; Laminin EGF domain
      pfam16489
      Location:22002448
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:25372561
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:25342786
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_006511622.1XP_006511685.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X3

      Conserved Domains (9) summary
      smart00303
      Location:24692522
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:646743
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:21172176
      HormR; Domain present in hormone receptors
      cd00054
      Location:17171748
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20672105
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:15081691
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00002
      Location:25292761
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam00053
      Location:19942033
      Laminin_EGF; Laminin EGF domain
      pfam16489
      Location:21962441
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    4. XM_006511623.1XP_006511686.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X4

      Conserved Domains (9) summary
      smart00303
      Location:24692522
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:646743
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:21172176
      HormR; Domain present in hormone receptors
      cd00054
      Location:17171748
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20672105
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:15081691
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00002
      Location:25292760
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam00053
      Location:19942033
      Laminin_EGF; Laminin EGF domain
      pfam16489
      Location:21962441
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    5. XM_006511625.2XP_006511688.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X5

      Conserved Domains (9) summary
      smart00303
      Location:24742527
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:646743
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:21172181
      HormR; Domain present in hormone receptors
      cd00054
      Location:17171748
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20672105
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:15081691
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00002
      Location:25342722
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam00053
      Location:19942033
      Laminin_EGF; Laminin EGF domain
      pfam16489
      Location:22012446
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    6. XM_006511626.1XP_006511689.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X6

      Conserved Domains (5) summary
      cd11304
      Location:646743
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:17171748
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20302053
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:15081691
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:19942033
      Laminin_EGF; Laminin EGF domain

    RNA

    1. XR_001778787.1 RNA Sequence

    2. XR_001778786.1 RNA Sequence

    3. XR_379754.1 RNA Sequence

    Reference GRCm38.p4 PATCHES

    Genomic

    1. NW_012132906.1 Reference GRCm38.p4 PATCHES

      Range
      41366..68015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_080437.2: Suppressed sequence

      Description
      NM_080437.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Support Center