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    SRSF10 serine and arginine rich splicing factor 10 [ Homo sapiens (human) ]

    Gene ID: 10772, updated on 5-Sep-2021

    Summary

    Official Symbol
    SRSF10provided by HGNC
    Official Full Name
    serine and arginine rich splicing factor 10provided by HGNC
    Primary source
    HGNC:HGNC:16713
    See related
    Ensembl:ENSG00000188529 MIM:605221
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149
    Summary
    This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 28.7), lymph node (RPKM 12.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SRSF10 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (23964347..23980370, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24290837..24306817, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3 histone pseudogene 1 Neighboring gene proline rich nuclear receptor coactivator 2 Neighboring gene uncharacterized LOC105378615 Neighboring gene ribosomal protein L36 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of serine/arginine-rich splicing factor 10 (SRSF10, FUSIP1) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ30749, FLJ43846, DKFZp686H0644

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables RS domain binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 10
    Names
    40 kDa SR-repressor protein
    FUS interacting protein (serine-arginine rich) 1
    FUS-interacting protein (serine-arginine rich) 2
    SR splicing factor 10
    TLS-associated SR protein
    TLS-associated protein TASR
    TLS-associated protein with SR repeats
    TLS-associated protein with Ser-Arg repeats
    TLS-associated serine-arginine protein 1
    TLS-associated serine-arginine protein 2
    neural-salient SR protein
    protein phosphatase 1, regulatory subunit 149
    serine-arginine repressor protein (40 kDa)
    splicing factor SRp38
    splicing factor, arginine/serine-rich 13
    splicing factor, arginine/serine-rich 13A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191005.3NP_001177934.1  serine/arginine-rich splicing factor 10 isoform 3

      See identical proteins and their annotated locations for NP_001177934.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 2. The encoded isoform (3) is shorter than isoform 2.
      Source sequence(s)
      AK001656, AL590609
      Consensus CDS
      CCDS53282.1
      UniProtKB/Swiss-Prot
      O75494
      Related
      ENSP00000344149.4, ENST00000343255.9
      Conserved Domains (1) summary
      cl17169
      Location:599
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_001191006.3NP_001177935.1  serine/arginine-rich splicing factor 10 isoform 4

      See identical proteins and their annotated locations for NP_001177935.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AK093226, AL590609, BC010074
      Consensus CDS
      CCDS53283.1
      UniProtKB/Swiss-Prot
      O75494
      Related
      ENSP00000363576.5, ENST00000374452.9
      Conserved Domains (1) summary
      cl17169
      Location:599
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_001191007.3NP_001177936.1  serine/arginine-rich splicing factor 10 isoform 5

      See identical proteins and their annotated locations for NP_001177936.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site and lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AK093226, AL590609, AY007101
      Consensus CDS
      CCDS53281.1
      UniProtKB/Swiss-Prot
      O75494
      Related
      ENSP00000388991.3, ENST00000453840.7
      Conserved Domains (1) summary
      cl17169
      Location:599
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. NM_001191009.3NP_001177938.1  serine/arginine-rich splicing factor 10 isoform 6

      See identical proteins and their annotated locations for NP_001177938.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (6) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AK296175, AL590609, AY007101
      Consensus CDS
      CCDS53280.1
      UniProtKB/Swiss-Prot
      O75494
      Related
      ENSP00000419813.2, ENST00000484146.6
      Conserved Domains (1) summary
      cd12559
      Location:599
      RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins
    5. NM_001300936.2NP_001287865.1  serine/arginine-rich splicing factor 10 isoform 8

      See identical proteins and their annotated locations for NP_001287865.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate in-frame splice site and lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (8) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AL590609
      Consensus CDS
      CCDS72728.1
      UniProtKB/TrEMBL
      Q5JRI1
      Related
      ENSP00000363577.3, ENST00000374453.7
      Conserved Domains (1) summary
      cl17169
      Location:1093
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. NM_001300937.2NP_001287866.1  serine/arginine-rich splicing factor 10 isoform 9

      See identical proteins and their annotated locations for NP_001287866.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (9) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AL590609
      Conserved Domains (1) summary
      cl17169
      Location:599
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. NM_006625.6NP_006616.1  serine/arginine-rich splicing factor 10 isoform 1

      See identical proteins and their annotated locations for NP_006616.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (1) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AF419331, AL590609
      Consensus CDS
      CCDS30629.1
      UniProtKB/Swiss-Prot
      O75494
      Related
      ENSP00000342913.5, ENST00000344989.10
      Conserved Domains (1) summary
      cd12559
      Location:599
      RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins
    8. NM_054016.4NP_473357.1  serine/arginine-rich splicing factor 10 isoform 2

      See identical proteins and their annotated locations for NP_473357.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AK093226, AL590609, BC005039
      Consensus CDS
      CCDS30630.1
      UniProtKB/Swiss-Prot
      O75494
      UniProtKB/TrEMBL
      A0A0S2Z504
      Related
      ENSP00000420195.1, ENST00000492112.3
      Conserved Domains (1) summary
      cl17169
      Location:599
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. NR_034035.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains multiple differences at both the 5' and 3' ends, compared to variant 2. This variant is represented as non-coding because the longest in-frame ORF does not meet RefSeq quality criteria.
      Source sequence(s)
      AK093226, AL590609, AY007101

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      23964347..23980370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000102.2XP_016855591.1  serine/arginine-rich splicing factor 10 isoform X1

      UniProtKB/TrEMBL
      B3KNY6
    2. XM_017000101.2XP_016855590.1  serine/arginine-rich splicing factor 10 isoform X1

      UniProtKB/TrEMBL
      B3KNY6
    3. XM_017000100.2XP_016855589.1  serine/arginine-rich splicing factor 10 isoform X1

      UniProtKB/TrEMBL
      B3KNY6
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