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    CENPB centromere protein B [ Homo sapiens (human) ]

    Gene ID: 1059, updated on 4-Nov-2018

    Summary

    Official Symbol
    CENPBprovided by HGNC
    Official Full Name
    centromere protein Bprovided by HGNC
    Primary source
    HGNC:HGNC:1852
    See related
    Ensembl:ENSG00000125817 MIM:117140; Vega:OTTHUMG00000031761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]
    Orthologs

    Genomic context

    See CENPB in Genome Data Viewer
    Location:
    20p13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (3783851..3786690, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3764498..3767337, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene chromosome 20 open reading frame 27 Neighboring gene sperm flagellar 1 Neighboring gene cell division cycle 25B Neighboring gene long intergenic non-protein coding RNA 1730 Neighboring gene nonconserved acetylation island sequence 110 enhancer

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    centromeric DNA binding IC
    Inferred by Curator
    more info
    PubMed 
    chromatin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    satellite DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed nuclear chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nuclear pericentric heterochromatin IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    major centromere autoantigen B
    Names
    CENP-B
    centromere autoantigen B
    centromere protein B, 80kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001810.5NP_001801.1  major centromere autoantigen B

      See identical proteins and their annotated locations for NP_001801.1

      Status: REVIEWED

      Source sequence(s)
      BC003649, BC053847
      Consensus CDS
      CCDS13064.1
      UniProtKB/Swiss-Prot
      P07199
      Related
      ENSP00000369075.4, OTTHUMP00000030132, ENST00000379751.4, OTTHUMT00000077772
      Conserved Domains (4) summary
      smart00674
      Location:74135
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam03184
      Location:222384
      DDE_1; DDE superfamily endonuclease
      pfam04218
      Location:256
      CENP-B_N; CENP-B N-terminal DNA-binding domain
      pfam09026
      Location:539598
      CENP-B_dimeris; Centromere protein B dimerization domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

      Range
      3783851..3786690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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