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    Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 102626, updated on 12-Aug-2018

    Summary

    Official Symbol
    Mapkapk3provided by MGI
    Official Full Name
    mitogen-activated protein kinase-activated protein kinase 3provided by MGI
    Primary source
    MGI:MGI:2143163
    See related
    Ensembl:ENSMUSG00000032577 Vega:OTTMUSG00000030250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3PK; MK3; MK-3; MAPKAP3; AI874665; MAPKAP-K3; MapkKapk3
    Expression
    Broad expression in colon adult (RPKM 18.4), bladder adult (RPKM 12.5) and 22 other tissues See more
    Orthologs

    Genomic context

    See Mapkapk3 in Genome Data Viewer
    Location:
    9; 9 F1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (107254926..107289877, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (107157258..107192208, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene dedicator of cyto-kinesis 3 Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 pseudogene Neighboring gene myc-like oncogene, s-myc protein pseudogene Neighboring gene predicted gene 17040 Neighboring gene cytokine inducible SH2-containing protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    macropinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    MAP kinase-activated protein kinase 3
    Names
    MAPK-activated protein kinase 3
    MAPKAP kinase 3
    MAPKAPK-3
    NP_001303620.1
    NP_849238.1
    XP_006511679.1
    XP_006511680.1
    XP_006511681.1
    XP_006511682.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316691.1NP_001303620.1  MAP kinase-activated protein kinase 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive coding exons in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. This variant is described in PMID:20570725.
      Source sequence(s)
      AK087496, AK151881, AL672070, DQ899946
      Consensus CDS
      CCDS85722.1
      UniProtKB/Swiss-Prot
      Q3UMW7
      UniProtKB/TrEMBL
      Q09HN3
      Related
      ENSMUSP00000141342.1, OTTMUSP00000069248, ENSMUST00000192054.1, OTTMUST00000128768
      Conserved Domains (2) summary
      smart00220
      Location:45237
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:41258
      PKc_like; Protein Kinases, catalytic domain
    2. NM_178907.3NP_849238.1  MAP kinase-activated protein kinase 3 isoform 1

      See identical proteins and their annotated locations for NP_849238.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK151881, AL672070
      Consensus CDS
      CCDS23487.1
      UniProtKB/Swiss-Prot
      Q3UMW7
      Related
      ENSMUSP00000035194.2, OTTMUSP00000039153, ENSMUST00000035194.7, OTTMUST00000074887
      Conserved Domains (2) summary
      smart00220
      Location:45306
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:41306
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      107254926..107289877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511618.3XP_006511681.1  MAP kinase-activated protein kinase 3 isoform X3

      Conserved Domains (2) summary
      smart00220
      Location:24245
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14089
      Location:10244
      STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases
    2. XM_006511619.1XP_006511682.1  MAP kinase-activated protein kinase 3 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:1198
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1197
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006511617.3XP_006511680.1  MAP kinase-activated protein kinase 3 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:29250
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14089
      Location:20249
      STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases
    4. XM_006511616.3XP_006511679.1  MAP kinase-activated protein kinase 3 isoform X1

      See identical proteins and their annotated locations for XP_006511679.1

      UniProtKB/Swiss-Prot
      Q3UMW7
      Conserved Domains (2) summary
      smart00220
      Location:45306
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:41306
      PKc_like; Protein Kinases, catalytic domain
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