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    TIMM17B translocase of inner mitochondrial membrane 17B [ Homo sapiens (human) ]

    Gene ID: 10245, updated on 15-Jul-2021

    Summary

    Official Symbol
    TIMM17Bprovided by HGNC
    Official Full Name
    translocase of inner mitochondrial membrane 17Bprovided by HGNC
    Primary source
    HGNC:HGNC:17310
    See related
    Ensembl:ENSG00000126768 MIM:300249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JM3; TIM17B; DXS9822
    Summary
    This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in heart (RPKM 15.4), prostate (RPKM 13.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TIMM17B in Genome Data Viewer
    Location:
    Xp11.23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (48893447..48898143, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48750730..48755426, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ES cell expressed Ras Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene polyglutamine binding protein 1 Neighboring gene solute carrier family 35 member A2 Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of translocase of inner mitochondrial membrane 17 homolog B (TIMM17B) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim17-B
    Names
    inner mitochondrial membrane preprotein translocase
    translocase of inner mitochondrial membrane 17 homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015968.2 RefSeqGene

      Range
      5007..9701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001167947.2NP_001161419.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 1

      See identical proteins and their annotated locations for NP_001161419.1

      Status: REVIEWED

      Source sequence(s)
      AF034790, AJ005895, CA421979, CB993524
      Consensus CDS
      CCDS55411.1
      UniProtKB/Swiss-Prot
      O60830
      Related
      ENSP00000379999.3, ENST00000396779.7
      Conserved Domains (1) summary
      cl02381
      Location:1221
      Tim17; Tim17/Tim22/Tim23/Pmp24 family
    2. NM_001395497.1NP_001382426.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC233300
    3. NM_001395498.1NP_001382427.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC233300
    4. NM_005834.5NP_005825.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 2

      See identical proteins and their annotated locations for NP_005825.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2, also known as hTim17b) is shorter than isoform 1.
      Source sequence(s)
      AF034790, AJ005895
      Consensus CDS
      CCDS14308.1
      UniProtKB/Swiss-Prot
      O60830
      Related
      ENSP00000365766.3, ENST00000376582.7
      Conserved Domains (1) summary
      cl02381
      Location:1171
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      48893447..48898143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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