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    Ces2a carboxylesterase 2A [ Mus musculus (house mouse) ]

    Gene ID: 102022, updated on 23-May-2018

    Summary

    Official Symbol
    Ces2aprovided by MGI
    Official Full Name
    carboxylesterase 2Aprovided by MGI
    Primary source
    MGI:MGI:2142491
    See related
    Ensembl:ENSMUSG00000055730 Vega:OTTMUSG00000027410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ces6; AI266984; 9130231C15Rik
    Expression
    Biased expression in liver adult (RPKM 135.2), duodenum adult (RPKM 127.9) and 5 other tissues See more

    Genomic context

    See Ces2a in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (104734003..104741634)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (107257903..107265534)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2A pseudogene Neighboring gene carboxylesterase 2E pseudogene Neighboring gene carboxylesterase 2 pseudogene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene RIKEN cDNA 4932416K20 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    carboxylic ester hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    trans-permethrin hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein glycosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    pyrethroid hydrolase Ces2a
    Names
    carboxylesterase 6
    NP_001177259.1
    NP_598721.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190330.1NP_001177259.1  pyrethroid hydrolase Ces2a isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK078953, AK165784, BY088529, BY458169
      Consensus CDS
      CCDS52650.1
      UniProtKB/Swiss-Prot
      Q8QZR3
      Related
      ENSMUSP00000127346.2, ENSMUST00000164182.2
      Conserved Domains (2) summary
      COG0657
      Location:127230
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:30504
      COesterase; Carboxylesterase family
    2. NM_133960.5NP_598721.1  pyrethroid hydrolase Ces2a isoform 1 precursor

      See identical proteins and their annotated locations for NP_598721.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK078953, BY088529, BY458169
      Consensus CDS
      CCDS22585.1
      UniProtKB/Swiss-Prot
      Q8QZR3
      Related
      ENSMUSP00000034346.7, OTTMUSP00000034180, ENSMUST00000034346.14, OTTMUST00000067808
      Conserved Domains (2) summary
      COG0657
      Location:127230
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:30537
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      104734003..104741634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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