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    PMS2 PMS1 homolog 2, mismatch repair system component [ Gallus gallus (chicken) ]

    Gene ID: 101752182, updated on 26-Feb-2019

    Summary

    Symbol
    PMS2provided by CGNC
    Full Name
    PMS1 homolog 2, mismatch repair system componentprovided by CGNC
    Primary source
    CGNC:71591
    See related
    Ensembl:ENSGALG00000003430
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PMS2P11
    Orthologs

    Genomic context

    See PMS2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 14 NC_006101.5 (1382466..1394788)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 14 NC_006101.4 (979239..991477)
    102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 14 NC_006101.3 (977534..989488)

    Chromosome 14 - NC_006101.5Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene aminoacyl tRNA synthetase complex interacting multifunctional protein 2 Neighboring gene radial spoke head 10 homolog B Neighboring gene CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) Neighboring gene uncharacterized LOC112533467 Neighboring gene oncomodulin

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem (from KEGG)
      BRCA1-associated genome surveillance complex (BASC), organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • BRCA1-associated genome surveillance complex (BASC), conserved biosystem (from KEGG)
      BRCA1-associated genome surveillance complex (BASC), conserved biosystemStructural complex; Genetic information processing; Repair system
    • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
      Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Fanconi anemia pathway, conserved biosystem (from KEGG)
      Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Mismatch repair, organism-specific biosystem (from KEGG)
      Mismatch repair, organism-specific biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
    • Mismatch repair, conserved biosystem (from KEGG)
      Mismatch repair, conserved biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MutSalpha complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    single base insertion or deletion binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    NOT gene conversion of immunoglobulin genes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic G2 DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleic acid phosphodiester bond hydrolysis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic hypermutation of immunoglobulin genes IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    MutLalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    mismatch repair complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mismatch repair endonuclease PMS2
    Names
    DNA mismatch repair protein PMS2
    PMS1 homolog 2, mismatch repair system component pseudogene 11
    PMS1 protein homolog 2
    PMS2 postmeiotic segregation increased 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319022.1NP_001305951.1  mismatch repair endonuclease PMS2

      Status: PROVISIONAL

      Source sequence(s)
      AJ720540
      UniProtKB/Swiss-Prot
      F1NQJ3
      Conserved Domains (4) summary
      smart00853
      Location:699830
      MutL_C; MutL C terminal dimerisation domain
      cd03484
      Location:223365
      MutL_Trans_hPMS_2_like; MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second ...
      TIGR00585
      Location:12345
      mutl; DNA mismatch repair protein MutL
      cl00075
      Location:33138
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006101.5 Reference GRCg6a Primary Assembly

      Range
      1382466..1394788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015294281.2XP_015149767.1  mismatch repair endonuclease PMS2 isoform X1

      UniProtKB/Swiss-Prot
      F1NQJ3
      Related
      ENSGALP00000005417.6, ENSGALT00000005427.6
      Conserved Domains (4) summary
      smart00853
      Location:685828
      MutL_C; MutL C terminal dimerisation domain
      cd03484
      Location:221363
      MutL_Trans_hPMS_2_like; MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second ...
      TIGR00585
      Location:12343
      mutl; DNA mismatch repair protein MutL
      cl00075
      Location:33138
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
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