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    CDK2 cyclin dependent kinase 2 [ Homo sapiens (human) ]

    Gene ID: 1017, updated on 12-Sep-2021

    Summary

    Official Symbol
    CDK2provided by HGNC
    Official Full Name
    cyclin dependent kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:1771
    See related
    Ensembl:ENSG00000123374 MIM:116953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDKN2; p33(CDK2)
    Summary
    This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in placenta (RPKM 29.3), bone marrow (RPKM 14.9) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CDK2 in Genome Data Viewer
    Location:
    12q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (55966830..55972789)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56360614..56366573)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase alpha Neighboring gene premelanosome protein Neighboring gene RAB13, member RAS oncogene family pseudogene Neighboring gene RAB5B, member RAS oncogene family Neighboring gene sulfite oxidase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.
    GeneReviews: Not available
    Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
    GeneReviews: Not available
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    GeneReviews: Not available
    Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat CDK2 regulates HIV-1 Tat-mediated transcription by phosphorylation of CDK9 at position Ser90 and decreases 7SK RNA levels PubMed
    tat Iron chelators 311 and ICL670 decrease cellular activity of CDK2 and reduce HIV-1 Tat phosphorylation by CDK2 PubMed
    tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
    tat Amino acid residues serine 16 and 46 of HIV-1 Tat are phosphorylated by CDK2; mutation of these two residues reduces HIV-1 transcription in cells PubMed
    tat HIV-1 Tat 41/44 peptide TAALS from the core domain of Tat inhibits Tat-mediated HIV-1 gene expression and replication by binding the Cdk2/Cyclin E complex and inhibiting the phosphorylation of serine 5 of RNAPII PubMed
    tat Cdk2 phosphorylates HIV-1 Tat PubMed
    tat Cdk2/cyclin E stimulates Tat-dependent HIV-1 transcription PubMed
    tat Tat-mediated phosphorylation of RNA Polymerase C-terminal domain involves dynamic interactions of Cdk2 with Tat amino acids 15-24 and 36-49 and requires cysteine 22 in the activation domain of Tat and amino acids 42-72 of Tat PubMed
    tat HIV-1 Tat induces Cdk2 to phosphorylate the RNA Polymerase C-terminal domain PubMed
    tat Cdk2 activity is enhanced by HIV-1 Tat expression in Jurkat T cells and is associated with Tat-induced apoptosis PubMed
    tat HIV-1 Tat induces Cyclin E-associated cdk activity in lymphocytes, indicating Tat drives cells to the late G1 phase of the cell cycle PubMed
    tat HIV-1 Tat induces a G1 arrest in cells of glial origin, leading to a downregulation of cyclin E-Cdk2 kinase activity and phosphorylation of Rb PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cyclin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    contributes_to histone kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in G2/M transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nitric oxide TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular senescence TAS
    Traceable Author Statement
    more info
     
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome duplication TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in histone phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in meiotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic G1 DNA damage checkpoint signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of anaphase-promoting complex-dependent catabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of gene silencing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    located_in centrosome TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of cyclin A1-CDK2 complex IDA
    Inferred from Direct Assay
    more info
     
    part_of cyclin A2-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cyclin E1-CDK2 complex IDA
    Inferred from Direct Assay
    more info
     
    part_of cyclin E2-CDK2 complex IDA
    Inferred from Direct Assay
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-dependent kinase 2
    Names
    cdc2-related protein kinase
    cell division protein kinase 2
    p33 protein kinase
    NP_001277159.1
    NP_001789.2
    NP_439892.2
    XP_011536034.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034014.1 RefSeqGene

      Range
      5062..11021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290230.2NP_001277159.1  cyclin-dependent kinase 2 isoform 3

      See identical proteins and their annotated locations for NP_001277159.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AA789250, AK293246, BC003065, DA814453
      Consensus CDS
      CCDS76567.1
      UniProtKB/Swiss-Prot
      P24941
      UniProtKB/TrEMBL
      B4DDL9, E7ESI2
      Related
      ENSP00000393605.2, ENST00000440311.6
      Conserved Domains (1) summary
      cl21453
      Location:3226
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001798.5NP_001789.2  cyclin-dependent kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_001789.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA789250, AK291941, BC003065, DA814453
      Consensus CDS
      CCDS8898.1
      UniProtKB/Swiss-Prot
      P24941
      UniProtKB/TrEMBL
      A0A024RB77
      Related
      ENSP00000266970.4, ENST00000266970.9
      Conserved Domains (1) summary
      cd07860
      Location:3286
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
    3. NM_052827.4NP_439892.2  cyclin-dependent kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_439892.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as CDK2deltaT) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2, also known as d-HSCDK2) is shorter than isoform 1.
      Source sequence(s)
      AA789250, AB012305, BC003065, DA814453
      Consensus CDS
      CCDS8899.1
      UniProtKB/Swiss-Prot
      P24941
      UniProtKB/TrEMBL
      A0A024RB10
      Related
      ENSP00000243067.4, ENST00000354056.4
      Conserved Domains (1) summary
      cl21453
      Location:3252
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      55966830..55972789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537732.2XP_011536034.1  cyclin-dependent kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_011536034.1

      UniProtKB/TrEMBL
      G3V5T9
      Related
      ENSP00000452514.1, ENST00000553376.5
      Conserved Domains (1) summary
      cd07860
      Location:3334
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
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