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    Pot1a protection of telomeres 1A [ Mus musculus (house mouse) ]

    Gene ID: 101185, updated on 5-Aug-2018

    Summary

    Official Symbol
    Pot1aprovided by MGI
    Official Full Name
    protection of telomeres 1Aprovided by MGI
    Primary source
    MGI:MGI:2141503
    See related
    Ensembl:ENSMUSG00000029676 Vega:OTTMUSG00000023472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pot1; AI851169; 1500031H18Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 7.1), liver E14.5 (RPKM 6.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See Pot1a in Genome Data Viewer
    Location:
    6; 6 A3.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (25743735..25809277, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (25693735..25759226, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30658 Neighboring gene G protein-coupled receptor 37 Neighboring gene predicted gene, 20756 Neighboring gene PCNA-associated factor pseudogene Neighboring gene predicted gene, 30779

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    8-hydroxy-2'-deoxyguanosine DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DEAD/H-box RNA helicase binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    G-rich single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-rich strand telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G-rich strand telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    telomerase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomerase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    telomeric D-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    establishment of protein localization to telomere ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of telomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA strand elongation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    telomere assembly ISO
    Inferred from Sequence Orthology
    more info
     
    telomere capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    telomeric D-loop disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    NOT telomeric loop formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT telomeric loop formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear telomere cap complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear telomere cap complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear telomere cap complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    shelterin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protection of telomeres protein 1
    Names
    POT1-like telomere end-binding protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133931.5NP_598692.1  protection of telomeres protein 1

      See identical proteins and their annotated locations for NP_598692.1

      Status: VALIDATED

      Source sequence(s)
      AC153888, AC158683
      Consensus CDS
      CCDS39442.1
      UniProtKB/Swiss-Prot
      Q91WC1
      Related
      ENSMUSP00000110986.1, OTTMUSP00000027510, ENSMUST00000115330.7
      Conserved Domains (2) summary
      smart00976
      Location:11141
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:153299
      POT1PC; ssDNA-binding domain of telomere protection protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      25743735..25809277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504956.2XP_006505019.1  protection of telomeres protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006505019.1

      Conserved Domains (2) summary
      smart00976
      Location:182
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:94240
      POT1PC; ssDNA-binding domain of telomere protection protein
    2. XM_006504955.2XP_006505018.1  protection of telomeres protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006505018.1

      Conserved Domains (2) summary
      smart00976
      Location:182
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:94240
      POT1PC; ssDNA-binding domain of telomere protection protein

    RNA

    1. XR_377283.2 RNA Sequence

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