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    HES1 hes family bHLH transcription factor 1 [ Ovis aries (sheep) ]

    Gene ID: 101106560, updated on 1-Jun-2019

    Summary

    Gene symbol
    HES1
    Gene description
    hes family bHLH transcription factor 1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs

    Genomic context

    See HES1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    103 current Oar_rambouillet_v1.0 (GCF_002742125.1) 1 NC_040252.1 (211456028..211458535, complement)
    102 previous assembly Oar_v4.0 (GCF_000298735.2) 1 NC_019458.2 (191456427..191458414, complement)

    Chromosome 1 - NC_040252.1Genomic Context describing neighboring genes Neighboring gene carboxypeptidase N subunit 2 Neighboring gene uncharacterized LOC105602482 Neighboring gene uncharacterized LOC114113790 Neighboring gene uncharacterized LOC114113793

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sheep Tissue Atlas
    • Description: Sheep total RNA was extracted from embryonic and adult tissues
    • BioProject: PRJEB6169
    • Publication: PMID 24904168
    • Analysis date: Mon Jan 29 09:33:46 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
      Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Fanconi anemia pathway, conserved biosystem (from KEGG)
      Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Maturity onset diabetes of the young, organism-specific biosystem (from KEGG)
      Maturity onset diabetes of the young, organism-specific biosystemAbout 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MO...
    • Maturity onset diabetes of the young, conserved biosystem (from KEGG)
      Maturity onset diabetes of the young, conserved biosystemAbout 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MO...
    • Notch signaling pathway, organism-specific biosystem (from KEGG)
      Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, conserved biosystem (from KEGG)
      Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...

    General protein information

    Preferred Names
    transcription factor HES-1
    Names
    hairy and enhancer of split 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Ovis aries Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Oar_rambouillet_v1.0 Primary Assembly

    Genomic

    1. NC_040252.1 Reference Oar_rambouillet_v1.0 Primary Assembly

      Range
      211456028..211458535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004003033.4XP_004003082.3  transcription factor HES-1

      Conserved Domains (2) summary
      cd00083
      Location:3295
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam07527
      Location:110148
      Hairy_orange; Hairy Orange
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