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    BACE2 beta-secretase 2 [ Ovis aries (sheep) ]

    Gene ID: 101102027, updated on 11-May-2018

    Summary

    Gene symbol
    BACE2
    Gene description
    beta-secretase 2
    See related
    Ensembl:ENSOARG00000010129
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs

    Genomic context

    See BACE2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    102 current Oar_v4.0 (GCF_000298735.2) 1 NC_019458.2 (259280324..259390197)
    101 previous assembly Oar_v3.1 (GCF_000298735.1) 1 NC_019458.1 (259446965..259556576)

    Chromosome 1 - NC_019458.2Genomic Context describing neighboring genes Neighboring gene DS cell adhesion molecule Neighboring gene 40S ribosomal protein S3a-like Neighboring gene uncharacterized LOC101119693 Neighboring gene actin, cytoplasmic 1-like Neighboring gene family with sequence similarity 3 member B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sheep Tissue Atlas
    • Description: Sheep total RNA was extracted from embryonic and adult tissues
    • BioProject: PRJEB6169
    • Publication: PMID 24904168
    • Analysis date: Mon Jan 29 09:33:46 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...

    General protein information

    Preferred Names
    beta-secretase 2
    Names
    beta-site APP-cleaving enzyme 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Ovis aries Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Oar_v4.0 Primary Assembly

    Genomic

    1. NC_019458.2 Reference Oar_v4.0 Primary Assembly

      Range
      259280324..259390197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004003354.3XP_004003403.1  beta-secretase 2 isoform X1

      UniProtKB/TrEMBL
      W5PK88
      Related
      ENSOARP00000010859
      Conserved Domains (2) summary
      cd05473
      Location:10371
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
      pfam00026
      Location:13351
      Asp; Eukaryotic aspartyl protease

    Alternate Oori1

    Genomic

    1. NW_011942411.1 Alternate Oori1

      Range
      150523..261245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012135792.2XP_011991182.1  beta-secretase 2 isoform X2

      Conserved Domains (2) summary
      cd05473
      Location:85446
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
      pfam00026
      Location:88426
      Asp; Eukaryotic aspartyl protease
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