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    BRCA2 BRCA2 DNA repair associated [ Nomascus leucogenys (northern white-cheeked gibbon) ]

    Gene ID: 100601625, updated on 24-Jan-2019

    Summary

    Gene symbol
    BRCA2
    Gene description
    BRCA2 DNA repair associated
    See related
    Ensembl:ENSNLEG00000001048
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Nomascus leucogenys
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
    Orthologs

    Genomic context

    See BRCA2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    102 current Nleu_3.0 (GCF_000146795.2) 9 NC_019824.1 (6979136..7063480, complement)

    Chromosome 9 - NC_019824.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105738788 Neighboring gene NEDD4 binding protein 2 like 1 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1-like Neighboring gene zygote arrest 1 like Neighboring gene FRY microtubule binding protein Neighboring gene uncharacterized LOC105738792

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_019824.1 Chromosome 9 Reference Nleu_3.0

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
      Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Fanconi anemia pathway, conserved biosystem (from KEGG)
      Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Homologous recombination, organism-specific biosystem (from KEGG)
      Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homologous recombination, conserved biosystem (from KEGG)
      Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    breast cancer type 2 susceptibility protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Nleu_3.0

    Genomic

    1. NC_019824.1 Reference Nleu_3.0

      Range
      6979136..7063480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003270250.3XP_003270298.1  breast cancer type 2 susceptibility protein

      UniProtKB/TrEMBL
      G1QK32
      Related
      ENSNLEP00000001277.1, ENSNLET00000001353.2
      Conserved Domains (6) summary
      cd04494
      Location:28053055
      BRCA2DBD_OB2; BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...
      pfam00634
      Location:19732003
      BRCA2; BRCA2 repeat
      pfam09103
      Location:26712794
      BRCA-2_OB1; BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
      pfam09104
      Location:30583187
      BRCA-2_OB3; BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
      pfam09169
      Location:24822668
      BRCA-2_helical; BRCA2, helical
      cl12054
      Location:18181890
      Terminase_3; Phage terminase large subunit
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