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    ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase [ Nomascus leucogenys (northern white-cheeked gibbon) ]

    Gene ID: 100588798, updated on 19-Jan-2018

    Summary

    Gene symbol
    ABL2
    Gene description
    ABL proto-oncogene 2, non-receptor tyrosine kinase
    See related
    Ensembl:ENSNLEG00000015604
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Nomascus leucogenys
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
    Orthologs

    Genomic context

    See ABL2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    102 current Nleu_3.0 (GCF_000146795.2) 12 NC_019827.1 (23084562..23208297)

    Chromosome 12 - NC_019827.1Genomic Context describing neighboring genes Neighboring gene axonemal dynein light chain domain containing 1 Neighboring gene myocyte-specific enhancer factor 2A pseudogene Neighboring gene sterol O-acyltransferase 1 Neighboring gene UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1-like Neighboring gene protein SET pseudogene Neighboring gene torsin family 3 member A Neighboring gene FAM20B, glycosaminoglycan xylosylkinase

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_019827.1 Chromosome 12 Reference Nleu_3.0

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    General gene information

    Markers

    General protein information

    Preferred Names
    Abelson tyrosine-protein kinase 2
    Names
    v-abl Abelson murine leukemia viral oncogene homolog 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Nleu_3.0

    Genomic

    1. NC_019827.1 Reference Nleu_3.0

      Range
      23084562..23208297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012511593.1XP_012367047.1  Abelson tyrosine-protein kinase 2 isoform X1

      Related
      ENSNLEP00000018934.3, ENSNLET00000019886.3
      Conserved Domains (5) summary
      smart00808
      Location:10631182
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:281543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:288539
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_012511595.1XP_012367049.1  Abelson tyrosine-protein kinase 2 isoform X3

      Related
      ENSNLEP00000034235.1, ENSNLET00000034422.1
      Conserved Domains (5) summary
      smart00808
      Location:10421161
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:148241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:260522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:267518
      Pkinase_Tyr; Protein tyrosine kinase
    3. XM_012511598.1XP_012367052.1  Abelson tyrosine-protein kinase 2 isoform X6

      Related
      ENSNLEP00000046134.1, ENSNLET00000048999.1
      Conserved Domains (5) summary
      smart00808
      Location:9391058
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:148241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:260522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:267518
      Pkinase_Tyr; Protein tyrosine kinase
    4. XM_003258950.1XP_003258998.1  Abelson tyrosine-protein kinase 2 isoform X8

      Related
      ENSNLEP00000049163.1, ENSNLET00000041454.1
      Conserved Domains (4) summary
      cd09935
      Location:148241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      smart00221
      Location:267518
      STYKc; Protein kinase; unclassified specificity
      cd05052
      Location:260522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    5. XM_012511596.1XP_012367050.1  Abelson tyrosine-protein kinase 2 isoform X4

      UniProtKB/TrEMBL
      G1S0A6
      Conserved Domains (5) summary
      smart00808
      Location:9601079
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:281543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:288539
      Pkinase_Tyr; Protein tyrosine kinase
    6. XM_012511597.1XP_012367051.1  Abelson tyrosine-protein kinase 2 isoform X5

      Conserved Domains (5) summary
      smart00808
      Location:9451064
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:266528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:273524
      Pkinase_Tyr; Protein tyrosine kinase
    7. XM_012511599.1XP_012367053.1  Abelson tyrosine-protein kinase 2 isoform X7

      Related
      ENSNLEP00000024703.1, ENSNLET00000040220.1
      Conserved Domains (5) summary
      smart00808
      Location:9241043
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:133226
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:75128
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:245507
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:252503
      Pkinase_Tyr; Protein tyrosine kinase
    8. XM_012511594.1XP_012367048.1  Abelson tyrosine-protein kinase 2 isoform X2

      Related
      ENSNLEP00000035888.1, ENSNLET00000048126.1
      Conserved Domains (5) summary
      smart00808
      Location:10481167
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:266528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:273524
      Pkinase_Tyr; Protein tyrosine kinase
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